1 / 14

Dr Nisreen Alwan Wellcome Trust Clinical Research Fellow

Nutritional Epidemiology Group School of Food Science & Nutrition. An example of using data from multiple longitudinal studies to address a scientific hypothesis: Maternal iron in pregnancy and offspring’s cardiovascular risk. Dr Nisreen Alwan Wellcome Trust Clinical Research Fellow.

manju
Télécharger la présentation

Dr Nisreen Alwan Wellcome Trust Clinical Research Fellow

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Nutritional Epidemiology Group School of Food Science & Nutrition An example of using data from multiple longitudinal studies to address a scientific hypothesis:Maternal iron in pregnancy and offspring’s cardiovascular risk Dr Nisreen Alwan Wellcome Trust Clinical Research Fellow

  2. Nutritional Epidemiology Group School of Food Science & Nutrition Background • Iron deficiency is a common problem during pregnancy • No solid evidence to support routine iron supplementation programmes duringpregnancy in relation to offspring outcomes • Maternal nutrition during pregnancy is potentially linked to chronic disease risk in the offspring

  3. Nutritional Epidemiology Group School of Food Science & Nutrition Maternal iron deficiency during pregnancy and offspring health: findings from animal studies McArdle et al (2006). Fetal programming: causes and consequences as revealed by studies of dietary manipulation in rats – a review. Placenta (27): 56-60.

  4. Nutritional Epidemiology Group School of Food Science & Nutrition Hypothesis Maternal iron deficiency during pregnancy is linked to increased cardiovascular risk in the offspring

  5. Nutritional Epidemiology Group School of Food Science & Nutrition Aim Assess the relationship between maternal iron status / intake during pregnancy and both short-term and long-term cardiovascular risk indicators in the offspring

  6. Letter of invitation Recruitment 12-18/52 28/52 36/52 24-hour recall Conception Delivery CAT1 CAT2 CAT3 1274 low-risk pregnancies in Leeds: 2003-06

  7. Nutritional Epidemiology Group School of Food Science & Nutrition The CARE study • Dietary iron intake <UK RNI (14.8 mg/day) = 80% • More likely to be younger, lower socioeconomic profile • Less likely to take supplements during the 1st trimester • 24%, 15% & 8% took iron-containing supplements in 1st, 2nd & 3rd trimester • Total iron intake from diet and supplements associated with customised birthweightcentile (adjusted change = 2.5 centiles/10 mg, 95% CI: 0.4, 4.6) Alwan, NA et al (2011). Dietary iron intake during early pregnancy and birth outcomes in a cohort of British women. Human Reproduction, 26, 911.

  8. Nutritional Epidemiology Group School of Food Science & Nutrition UKWCS (Iron and blood pressure study) • UKWCS – 1st phase 35,372 women 35-69 years at recruitment across UK, 2nd phase 15,000 • C282Y is a common mutation (around 13% of Europeans), homozygotes more likely to develop haemochromatosis • C282Y heterozygotes are asymptomatic but less likely to be iron-deficient • C282Y used as an instrument for the exposure of interest (maternal iron status) to control for confounding

  9. Nutritional Epidemiology Group School of Food Science & Nutrition UKWCS (Iron and blood pressure study)

  10. Nutritional Epidemiology Group School of Food Science & Nutrition Baby’s Vascular health and Iron in Pregnancy study • Pulse wave velocity is a strong predictor of CVD mortality in adults, and has been linked to CV risk factors such as lipids, body fat, blood pressure & glucose in children • Retrospective cohort design • Outcome – Neonatal arterial stiffness (Brachio-femoral PWV) • Exposure – body iron stores in early pregnancy (serum transferrin receptor /serum ferritin) Vicorder kit

  11. Nutritional Epidemiology Group School of Food Science & Nutrition ALSPAC • Exposures: maternal dietary intake at 32 weeks gestation (FFQ), maternal supplement intake during pregnancy, maternal haemoglobin during pregnancy, cord ferritin • Outcomes: Offspring’s pulse wave velocity and flow mediated dilatation at 10-12 years • Potential mediators: maternal BMI, gestational age, birthweight, offspring dietary iron intake (FFQ)

  12. Nutritional Epidemiology Group School of Food Science & Nutrition Thank you n.alwan@leeds.ac.uk

More Related