1 / 21

Some new data too

Introduction to UK GO data GPRD: General Practice Research Database THIN: Health Improvement Network. Some new data too. Records from GP routine records GPRD=THIN (almost) >6% of the UK population >350 GP practices >6½ million individual people. Data sources.

manon
Télécharger la présentation

Some new data too

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Introduction to UK GO dataGPRD: General Practice Research DatabaseTHIN: Health Improvement Network Some new data too

  2. Records from GP routine records • GPRD=THIN (almost) • >6% of the UK population • >350 GP practices • >6½ million individual people Data sources

  3. Largest UK employer―4th largest employer in world • 1.7 million employees • 40,000 GPs • 10,000 GP practices • GPs see 140 patients per week UK NHS―National Health Service

  4. Diagnoses: GP and some hospital • Biochemistry: HbA1c etc • Risk factors: weight, smoking etc • Family history (some) • Drugs (all prescribed drugs) • Outpatient contacts • Free text • GPRD only….linked data: • Cancer registry data • Hospital inpatient data Data content

  5. Quality: representativeness

  6. Quality: completeness

  7. Quality: completeness

  8. Size―over 5% UK population • Nationally representative • Fast―information already collected • Frequent collections • All prescribable drugs • Population based • Study design flexibility • ‘Real Life’ data―collected during normal GP visit • Link to GP and patient for additional information Strengths

  9. £cost! • No direct link to secondary care data (THIN) • No direct link of prescriptions to diagnoses - temporal implied link • Limited information on OTC medications • Limited data on lifestyles, diet etc • Not dispensed prescriptions • Limited information on hospital prescribing • Some medications only administered by specialists Weaknesses

  10. Details of the cancer diagnosis variable • No systematic cancer staging data • Metastatic cancer: have to infer • Hospital cancer treatments not known Weaknesses re Ca.

  11. New data! Survival after incident cancer: diabetes vs. non-diabetes

  12. Incident cancers by cancer site

  13. Incident cancers by DM treatment

  14. Mean survival by Ca. site (years)

  15. Δ mean survival by Ca. site (years)

  16. Cumulative mortality (crude) DM Non-DM

  17. Cumulative mortality (adjusted) DM Non-DM Adjusted: age, sex, smoking, morbidity

  18. HR DM vs-N-DM (Cox)

  19. adjHR: DM vs N-DM (=1) by treatment

  20. Cum-mortality: ± metformin (adjusted) Met- Met- Met+ Met+ Exposed in first 3 months Exposed anytime aft Ca. diag HR=0.72; 0.68-0.76; p<0.00001 HR=0.83; 0.78-0.89; p<0.00001

More Related