1 / 13

Mathematics and Post-Genomic Biology

Mathematics and Post-Genomic Biology. Biology has changed. Biology is on the popular mind more than chemistry & physics these days Students don’t choose to study biology because they “like science but not the math” anymore. Growth of PDB. Data Poor → Data Rich.

margaretvernon
Télécharger la présentation

Mathematics and Post-Genomic Biology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Mathematics and Post-Genomic Biology

  2. Biology has changed • Biology is on the popular mind more than chemistry & physics these days • Students don’t choose to study biology because they “like science but not the math” anymore...

  3. Growth of PDB Data Poor → Data Rich • Not long ago, it could take a lifetime to gather even a small dataset relevant to understanding a living system…

  4. Post-Genomic Instruments Expression array “chips” 15,000+ genes/chip at $500/chip (and falling!) • High throughput SNP genotyping automation • $0.01/SNP and dropping fast • LC/MS/MS proteomics • Gigabyte / day of spectra!

  5. Biology’s “New Math” • Calculus matters, but less than in physics or chemistry… • Discrete math has a dramatically more important role, e.g. in sequence analysis and genetics • Due to its less “law-like” nature, understanding statistical inference is a critical basic skill for nearly all biology

  6. Lots of REAL data available free on the web • Students can do REAL scientific projects www.rcsb.org/pdbmetacyc.orgwww.uchsc.edu/sm/chs

  7. Great Web Resources

  8. New relevance opportunities • Based on news stories • Gene discoveries • Crime / DNA identification • Epidemics • Related to teen concerns • Genetics and sports / beauty • HIV / AIDS • Drugs, alcohol & tobacco http://www.gmathletes.net/

  9. Graphs & Cycles • Molecular biology is inherently network-y • Metabolism, Signaling and Regulatory networks • Functional/Semantic links • Evolutionary relationships • Other levels, too • Global carbon cycles • Neurons & synapses

  10. Genomic Combinations Humans have 40,877 proteins (a total of 18,311,133 amino acids); If the 20 characters are randomly distributed, what is the probabilityof seeing any particular 4 letter sequence? An 11 letter one?

  11. Drugs and Receptors HIV protease boundto Ritonavir • Geometry of interactions • Receptor bindingand pharmacodynamics • Drug trials, safety anddata interpretation http://www.mc.uky.edu/pharmacology/instruction/pha824mp

  12. Teamwork • Team science is growing in importance. Teams can work in teaching, too. • Coordination betweenteachers of math and biology • Studentteams doing complementary problems • Researcher / industry partnerships with schools,students and teachers http://www.succcessstories.com

  13. You have a critical role! • Good jobs are available for people with math and biology skills, at all levels • Health care, especially nursing • Biotech industry • Pharmaceuticals & pharmacists • Math/bio is an increasingly important competence for consumers & citizens • Informed patients get better health care • Public debates on epidemics, genetic modifications, etc.

More Related