1 / 13

The role of the oculomotor system in spatial working memory Daniel T. Smith Soazig Casteau

The role of the oculomotor system in spatial working memory Daniel T. Smith Soazig Casteau Neil Archibald. @ AttentionLab. This Photo by Unknown Author is licensed under CC BY. Progressive Supranuclear Palsy. Rare (~6/100000) degenerative brain disease Tau pathology

marilynd
Télécharger la présentation

The role of the oculomotor system in spatial working memory Daniel T. Smith Soazig Casteau

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The role of the oculomotor system in spatial working memory Daniel T. Smith SoazigCasteau Neil Archibald @AttentionLab This Photo by Unknown Author is licensed under CC BY

  2. Progressive Supranuclear Palsy • Rare (~6/100000) degenerative brain disease • Tau pathology • Brainstem, basal ganglia, spreads to frontal lobes, cerebellum • Motor problems, akinesia and rigidity in the neck. • Problems with swallowing, speech • Cognitive impairment • Vertical paralysis of gaze, eventually affects all saccades

  3. Oculomotor control & VSSTM • Oculomotor system active during spatial short-term memory • Overlapping neural substrates (e.g. Ikkai & Curtis, 2011) • Gaze directed to empty locations during STM tasks (Spivey & Geng 2001) • Disrupting oculomotor system impairs memory span (Pearson et al., 2014) • What is the functional role of this oculomotor activation? • Baddeley (1986): “Oculomotor loop” a rehearsal mechanism?

  4. Participants • 10 people with PSP (aged 55-79 mean 70) • 15 people with Parkinsons Disease (58-77, mean 68) • 14 age matched controls (55 – 72, mean 65) • Assessed range of eye-movements with EOG • No vertical saccades • Horizontal saccades slow & hypometric, left worse than right • Modified Corsi block task • Visual Search task

  5. Corsi Blocks task

  6. Results F = 18.97, p = .001 • Group x Array Orientation interaction (F = 3.87, p < .05) Smith & Archibald (2018). Spatial working memory in Progressive Supranuclear Palsy Cortex, in press.

  7. Discussion • PSP group had impairment of ~0.7 item on vertical axis • PD / AMC group no vertical impairment • Deficit similar magnitude to eye-abduction (Pearson et al., 2014) • Oculomotor system has reciprocal links with parietal cortex • PPC represents priority • Helps sustain delay period activity in priority map • Damage to oculomotor system disrupts feedback loop • Location information decays quickly, causing poor recall

  8. Imagery? • Oculomotor system implicated in some forms of imagery (e.g. Andrade, Kavanagh & Baddeley 1997) • Does disrupting oculomotor system also disrupt visual imagery? • Eye-abduction • PSP & Parkinson’s Disease • TMS • NINEDTP…

  9. Eye Abduction • Eye abduction paradigm (Craighero et al., 2004)

  10. Spatial Working Memory Visual Patterns Arrow Span Corsi Size

  11. Ball, Pearson & Smith (2013). Cognition, 129(2), 439-446.

More Related