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Understanding Genetic Modifications and Environmental Effects

Exploring how environmental factors impact genetic expression, allele values, and survivorship in different populations. Delve into interactions, adaptations, and the significance of sex determination.

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Understanding Genetic Modifications and Environmental Effects

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  1. IV. Modifications to Mendelian Patterns A. Intralocular Interactions B. Interlocular Interactions: C. Environmental Effects: The environment can influence how an allele is expressed and the effect it has.

  2. C. Environmental Effects: 1. TEMPERATURE - Siamese cats and Himalayan rabbits – dark feet and ears, where temps are slightly cooler. Their pigment enzymes function at cool temps. - Arctic fox, hares – their pigment genes function at high temps and are responsible for a change in coat color in spring and fall, and a change back to white in fall and winter.

  3. C. Environmental Effects: 1. TEMPERATURE 2. TOXINS, ALLERGENS: - people have genetically different sensitivities to different toxins. Certain genes are associated with higher rates of certain types of cancer, for example. However, they are not ‘deterministic’… their effects must be activated by some environmental variable. PKU = phenylketonuria… genetic inability to convert phenylalanine to tyrosine. Phenylalanine can build up and is toxic to nerve cells. Single gene recessive disorder. But if a homozygote recessive eats a diet low in phenylalanine, no negative consequences develop.

  4. IV. Modifications to Mendelian Patterns A. Intralocular Interactions B. Interlocular Interactions: C. Environmental Effects: D. The “Value” of an Allele: 1. There are obvious cases where genes are bad – lethal alleles 2. But there are also ‘conditional lethals’ that are only lethal under certain conditions – like temperature-sensitive lethals. 3. And for most genes, the relative value of one allele over another is determined by the relative effects of those genes in a particular environment.

  5. D. The “Value” of an Allele: 3. And for most genes, the relative value of one allele over another is determined by the relative effects of those genes in a particular environment. Survivorship in U.S., sickle-cell anemia (incomplete dominance, one gene ‘bad’, two ‘worse’) SS Ss ss

  6. D. The “Value” of an Allele: 3. And for most genes, the relative value of one allele over another is determined by the relative effects of those genes in a particular environment. Survivorship in U.S., sickle-cell anemia Survivorship in tropical Africa (incomplete dominance, one gene ‘bad’, (one gene ‘good’, two ‘bad’) two ‘worse’) SS Ss ss SS Ss ss

  7. D. The “Value” of an Allele: 3. And for most genes, the relative value of one allele over another is determined by the relative effects of those genes in a particular environment. Survivorship in U.S., sickle-cell anemia Survivorship in tropical Africa (incomplete dominance, one gene ‘bad’, (one gene ‘good’, two ‘bad’) two ‘worse’) Malaria is still the primary cause of death in tropical Africa (with AIDS). The malarial parasite can’t complete development in RBC’s with sickle cell hemoglobin… so one SC gene confers a resistance to malaria without the totally debilitating effects of sickle cell. SS Ss ss SS Ss ss

  8. D. The “Value” of an Allele: 3. And for most genes, the relative value of one allele over another is determined by the relative effects of those genes in a particular environment. Survivorship in U.S., sickle-cell anemia Survivorship in tropical Africa (incomplete dominance, one gene ‘bad’, (one gene ‘good’, two ‘bad’) two ‘worse’) As Darwin realized, selection will favor different organisms in different environments, causing populations to become genetically different over time. SS Ss ss SS Ss ss

  9. V. Sex Determination and Sex Linkage - Overview: Mendel’s reciprocal crosses showed that the transmission of many traits was not influenced by the sex of the parent, nor the sex of the offspring. However, there are situations where this is NOT the case…

  10. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex…

  11. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… 1. Why sex?

  12. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… 1. Why sex? - meiosis and sexual recombination during fertilization produces extraordinary variation which is adaptive in changing environments.

  13. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… 1. Why sex? - meiosis and sexual recombination during fertilization produces extraordinary variation which is adaptive in changing environments. 2. Why 2 sexes?

  14. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… 1. Why sex? - meiosis and sexual recombination during fertilization produces extraordinary variation which is adaptive in changing environments. 2. Why 2 sexes? - There aren’t always 2 sexes…. In many species there are multiple “mating types” (fungi, for example).

  15. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… 1. Why sex? - meiosis and sexual recombination during fertilization produces extraordinary variation which is adaptive in changing environments. 2. Why 2 sexes? - There aren’t always 2 sexes…. In many species there are multiple “mating types” (fungi, for example). - Multiple sexes have an advantage: there are more potential mates available (with the only restriction being that organisms of the same mating type can’t mate). 2 sexes, equally represented: 50% chance of meeting opposite sex 20 sexes, equal rep: 95% chance of meeting opposite sex Advantageous for org’s with restricted mobility (fungi growing through soil).

  16. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… 1. Why sex? - meiosis and sexual recombination during fertilization produces extraordinary variation which is adaptive in changing environments. 2. Why 2 sexes? - So, if multiple sexes is so great, why are most species 2-sexed?

  17. 2. Why 2 sexes? - So, if multiple sexes is so great, why are most species 2-sexed? - It may have to do with ‘cytoplasmic wars’

  18. 2. Why 2 sexes? - So, if multiple sexes is so great, why are most species 2-sexed? - It may have to do with ‘cytoplasmic wars’ When cells from different organisms contact one another, they can initiate a cellular ‘immune response’ – especially if they fuse. Proteins in the cytoplasm can be recognized as foreign and start a ‘cytoplasmic war’ between the cells.

  19. 2. Why 2 sexes? - So, if multiple sexes is so great, why are most species 2-sexed? - It may have to do with ‘cytoplasmic wars’ When cells from different organisms contact one another, they can initiate a cellular ‘immune response’ – especially if they fuse. Proteins in the cytoplasm can be recognized as foreign and start a ‘cytoplasmic war’ between the cells. A solution is for one cell to ‘unilaterally disarm’ and NOT donate cytoplasmic elements – just donate chromosomes.

  20. 2. Why 2 sexes? - So, if multiple sexes is so great, why are most species 2-sexed? - It may have to do with ‘cytoplasmic wars’ When cells from different organisms contact one another, they can initiate a cellular ‘immune response’ – especially if they fuse. Proteins in the cytoplasm can be recognized as foreign and start a ‘cytoplasmic war’ between the cells. A solution is for one cell to ‘unilaterally disarm’ and NOT donate cytoplasmic elements – just donate chromosomes. With multiple sexes, how are these decisions made? Consider a simple hierarchy:

  21. With multiple sexes, how are these decisions made? Consider a simple hierarchy: SEX 1 – NEVER DISARMS SEX 2 – Disarms for 1, not for 3-5. SEX 3 – Disarms for 1 and 2, not for 4-5. SEX 4 – Disarms for 1-3, not for 5. SEX 5 – ALWAYS DISARMS

  22. With multiple sexes, how are these decisions made? Consider a simple hierarchy: SEX 1 – NEVER DISARMS SEX 2 – Disarms for 1, not for 3-5. SEX 3 – Disarms for 1 and 2, not for 4-5. SEX 4 – Disarms for 1-3, not for 5. SEX 5 – ALWAYS DISARMS Sexes 2-4 have to make a choice; and we should expect some frequency of errors (because nothing is perfect). So, matings involving sexes 2-4 will have a lower frequency of successful fertilization than those involving 1 and 2.

  23. With multiple sexes, how are these decisions made? Consider a simple hierarchy: SEX 1 – NEVER DISARMS SEX 2 – Disarms for 1, not for 3-5. SEX 3 – Disarms for 1 and 2, not 4-5. SEX 4 – Disarms for 1-3, not 5. SEX 5 – ALWAYS DISARMS Sexes 2-4 have to make a choice; and we should expect some frequency of errors (because nothing is perfect). So, matings involving sexes 2-4 will have a lower frequency of successful fertilization than those involving 1 and 2. What do we call differential reproductive success?

  24. With multiple sexes, how are these decisions made? Consider a simple hierarchy: SEX 1 – NEVER DISARMS SEX 2 – Disarms for 1, not for 3-5. SEX 3 – Disarms for 1 and 2, not 4-5. SEX 4 – Disarms for 1-3, not 5. SEX 5 – ALWAYS DISARMS Sexes 2-4 have to make a choice; and we should expect some frequency of errors (because nothing is perfect). So, matings involving sexes 2-4 will have a lower frequency of successful fertilization than those involving 1 and 2. What do we call differential reproductive success? Riiiight…..Selection

  25. With multiple sexes, how are these decisions made? Consider a simple hierarchy: SEX 1 – NEVER DISARMS SEX 2 – Disarms for 1, not for 3-5. SEX 3 – Disarms for 1 and 2, not 4-5. SEX 4 – Disarms for 1-3, not 5. SEX 5 – ALWAYS DISARMS Sexes 2-4 have to make a choice; and we should expect some frequency of errors (because nothing is perfect). So, matings involving sexes 2-4 will have a lower frequency of successful fertilization than those involving 1 and 2. What do we call differential reproductive success? Riiiight…..Selection So what happens to the population?

  26. With multiple sexes, how are these decisions made? Consider a simple hierarchy: SEX 1 – NEVER DISARMS SEX 2 – Disarms for 1, not for 3-5. SEX 3 – Disarms for 1 and 2, not 4-5. SEX 4 – Disarms for 1-3, not 5. SEX 5 – ALWAYS DISARMS Sexes 2-4 have to make a choice; and we should expect some frequency of errors (because nothing is perfect). So, matings involving sexes 2-4 will have a lower frequency of successful fertilization than those involving 1 and 2. What do we call differential reproductive success? Riiiight…..Selection So what happens to the population? Right…. The population becomes dominated by two sexes; one that never disarms and always donates the cytoplasm (female and egg), and one that always disarms and gives nothing but chromosomes (male, sperm).

  27. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… B. Sex Determination

  28. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… B. Sex Determination 1. Environmental: - Temperature dependent sex determination in crocodilians, turtles, and some lizards:

  29. 1. Environmental: - Temperature dependent sex determination in crocodilians, turtles, and some lizards: How? – May involve temperature dependent enzymes (like aromatase) that convert testosterone to estrogen. Change in activity with temperature, like the genes for coat color in himalayan rabbits and arctic fox (also reverse effects there).

  30. 1. Environmental: - Temperature dependent sex determination in crocodilians, turtles, and some lizards: How? – May involve temperature dependent enzymes (like aromatase) that convert testosterone to estrogen. Change in acxtivty with temperature, like the genes for coat color in himalayan rabbits and arctic fox (also reverse effects there). Why? … when you see a non-random characteristic in organisms, what’s your hypothesis?

  31. 1. Environmental: - Temperature dependent sex determination in crocodilians, turtles, and some lizards: How? – May involve temperature dependent enzymes (like aromatase) that convert testosterone to estrogen. Change in acxtivty with temperature, like the genes for coat color in himalayan rabbits and arctic fox (also reverse effects there). Why? … when you see a non-random characteristic in organisms, what’s your hypothesis? …. Riiiight….selection. So why might it be adaptive, in terms of reproductive success?

  32. 1. Environmental: - Temperature dependent sex determination in crocodilians, turtles, and some lizards: Why? Crocs, turtles, and some lizards have a ‘polygynous’ mating system….

  33. 1. Environmental: - Temperature dependent sex determination in crocodilians, turtles, and some lizards: Why? Crocs, turtles, and some lizards have a ‘polygynous’ mating system…. One big male holds a territory and acquires and mates with most of the females in an area.

  34. 1. Environmental: - Temperature dependent sex determination in crocodilians, turtles, and some lizards: Why? Crocs, turtles, and some lizards have a ‘polygynous’ mating system…. One big male holds a territory and acquires and mates with most of the females in an area. SO! Daughters will probably mate, but only the rare son, who can acquire a harem, will mate. Daughters are a safe reproductive investment; sons are riskier, but with a potentially bigger reproductive payoff.

  35. Why? SO! A young female turtle digs a shallow nest – its warm – most her eggs develop as daughters. MT FT

  36. Why? SO! A young female turtle digs a shallow nest – its warm – most her eggs develop as daughters. This is adaptive, as most of her daughters will mate… she has gauranteed her reproductive success by making a safe investment early in life… MT FT

  37. Why? SO! As she ages, she grows larger, and digs a deeper nest with a higher fraction of males This is ALSO adaptive. Her daughters are also reproducing her genes. In fact, cumulatively, several reproducing daughters would produced more of her genes than she would each year! With her reproductive security assured, making males is low risk (if they don’t mate, no biggie), but it could pay off BIG (if they become a dominant male and mate ALOT.) MT FT

  38. Why? SO! As she ages, she grows larger, and digs a deeper nest with a higher fraction of males So, in their mating system, temperature dependent sex determination may be adaptive. MT FT

  39. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… B. Sex Determination 1. Environmental: - Temperature dependent: 2. Developmental: Hermaphrodites have both sex organs, but all their cells are the same genetically. The key is in differential gene activation in different tissues; just like tissue specialization for other tissue types.

  40. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… B. Sex Determination 1. Environmental: 2. Developmental: 3. Chromosomal: Sex correlates with a particular complement of chromosomes; suggesting that the genes that govern sexual development are all on this chromosome.

  41. V. Sex Determination and Sex Linkage - Overview: A. Some Questions About Sex… B. Sex Determination 1. Environmental: 2. Developmental: 3. Chromosomal: Sex correlates with a particular complement of chromosomes; suggesting that the genes that govern sexual development are all on this chromosome. NOTE that this is NOT equivalent to ‘genetic’ sex determination. In all cases presented above, sex determination is influenced by many genes; just that in some organisms the action of those genes is affected by temperature, or proteins/chemicals produced elsewhere in the organism, and the genes are not all concentrated on one chromosome.

  42. 3. Chromosomal: You are familiar with the ‘X – Y’ system, but there are several: a. Protenor sex determination: Sexes differ in chromosome number Order: Hemiptera “True Bugs” Family Alydidae – Broad-headed bugs

  43. 3. Chromosomal: You are familiar with the ‘X – Y’ system, but there are several: a. Protenor sex determination: Sexes differ in chromosome number b. Lygaeus sex determination: Sexes have different types of sex chromosomes – heterogametic and homogametic sexes… (Fowl: female=ZW, Male=ZZ) Order: Hemiptera Family: Lygaeidae “Chinch/Seed Bugs”

  44. 3. Chromosomal: You are familiar with the ‘X – Y’ system, but there are several: a. Protenor sex determination: Sexes differ in chromosome number b. Lygaeus sex determination: Sexes have different types of sex chromosomes – heterogametic and homogametic sexes… (Fowl: female=ZW, Male=ZZ) - Sex Determination in Humans:

  45. - Sex Determination in Humans: Lygaeus sex determination, whereby the presence of the Y determines maleness. transcribed Not transcribed

  46. - Sex Determination in Humans: Lygaeus sex determination, whereby the presence of the Y determines maleness. SRY – codes for a product called the ‘testis determining factor’ – triggers undifferentiated gonad to become testis.

  47. - Sex Determination in Humans: Lygaeus sex determination, whereby the presence of the Y determines maleness. Evidence: Some XY individuals lack the SRY region, or have a mutation in it, and they are phenotypically female. Some XX individuals have an sry that has been transposed, and they are phenotypically male. Experimental insertion of sry-homologs in mice stimulates XX embryos to become male. SRY – codes for a product called the ‘testis determining factor’ – triggers undifferentiated gonad to become testis.

  48. 3. Chromosomal: You are familiar with the ‘X – Y’ system, but there are several: a. Protenor sex determination: Sexes differ in chromosome number b. Lygaeus sex determination: Sexes have different types of sex chromosomes – heterogametic and homogametic sexes… (Fowl: female=ZW, Male=ZZ) c. Balanced sex determination (Drosophila): The ratio of autosomal sets to X chromosomes determines the sex:

  49. 3. Chromosomal: You are familiar with the ‘X – Y’ system, but there are several: a. Protenor sex determination: Sexes differ in chromosome number b. Lygaeus sex determination: Sexes have different types of sex chromosomes – heterogametic and homogametic sexes… (Fowl: female=ZW, Male=ZZ) c. Balanced sex determination (Drosophila): The ratio of autosomal sets to X chromosomes determines the sex:

  50. 3. Chromosomal: You are familiar with the ‘X – Y’ system, but there are several: a. Protenor sex determination: Sexes differ in chromosome number b. Lygaeus sex determination: Sexes have different types of sex chromosomes – heterogametic and homogametic sexes… (Fowl: female=ZW, Male=ZZ) c. Balanced sex determination (Drosophila): The ratio of autosomal sets to X chromosomes determines the sex: Governed by several genes on autosomes that are activated differently, and their transcripts are spliced differently, depending on the ratio of X/autosomal sets…suggesting there is another x-linked gene that might work in a dosage dependent way.

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