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Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1- 3 PROTON

Phase 2. Treatment Naïve . Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1- 3 PROTON. Lawitz E, et al. Lancet Infect Dis. 2013;13:401-8. Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1-3 PROTON Trial: Design. Source: Lawitz E, et al. Lancet Infect Dis. 2013;13:401-8.

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Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1- 3 PROTON

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  1. Phase 2 TreatmentNaïve Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1-3PROTON Lawitz E, et al. Lancet Infect Dis. 2013;13:401-8.

  2. Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1-3PROTON Trial: Design Source: Lawitz E, et al. Lancet Infect Dis. 2013;13:401-8.

  3. Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1-3PROTON Trial: Design 0 12 24 48 72 Week + RVR GT 1 SOF (200 mg) +PEG + RBV PEG + RBV n =48 - RVR PEG + RBV + RVR SOF (400 mg) +PEG + RBV PEG + RBV n =47 - RVR PEG + RBV SOF + PEG + RBV n =26 GT 2, 3 SOF + PEG + RBV n = 25 N =14 Drug DosingSofosbuvir (SOF): 400 mg once daily, except as designated in arm that received 200 mg once dailyRibavirin (RBV) weight-based and divided bid: 1000 mg/day if < 75 kg or 1200 mg/day if ≥ 75 kgPeginterferferon alfa-2a (PEG): 180 µg once weekly Source: Lawitz E, et al. Lancet Infect Dis. 2013;13:401-8.

  4. Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1-3PROTON Trial: Design PROTON: SVR 24 41/48 42/47 15/26 23/25 Genotype 1 Genotype 2 Source: Lawitz E, et al. Lancet Infect Dis. 2013;13:401-8.

  5. Sofosbuvir + Ribavirin + Peginterferon in Genotypes 1-3PROTON Trial: Conclusions Source: Lawitz E, et al. Lancet Infect Dis. 2013;13:401-8.

  6. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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