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Influenza Vaccine Responses

Influenza Vaccine Responses. Zhiping Ye, M.D., Ph.D. Division of Viral Products. Prepared for Vaccines and Related Biological Products Advisory Committee 17 February 2006. 1. 2005-2006 Vaccine Responses to Recent Influenza isolates.

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Influenza Vaccine Responses

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  1. Influenza Vaccine Responses Zhiping Ye, M.D., Ph.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee 17 February 2006 1

  2. 2005-2006 Vaccine Responses to Recent Influenza isolates • Panels of sera obtained from 2005-2006 influenza vaccinees were tested for their ability to inhibit heamagglutination of current influenza isolates • Post-vaccination antibody titer of current virus isolates compared to vaccine strain of virus (bold) • Lower titers (italic) indicate poor antibody inhibition of tested virus isolates 2

  3. Serum Panels for Serologies 1. AUSTRALIA IAN BARR, PH.D. ADULTS A/NEW CALEDONIA/20/99 (H1N1) WHO, AUSTRALIA ELDERLY A/WELLINGTON/01/04 (H3N2) B/JIANSU/10/03 2. EUROPE JOHN WOOD, PH.D. ADULTS A/NEW CALEDONIA/20/99 (H1N1) NIBSC, ENGLAND ELDERLY A/NEW YORK/55/04 (H3N2) B/JIANGSU/10/03 3. JAPAN TAKATO ODIGARI, PH.D. ADULTS A/NEW CALEDONIA/20/99 (H1N1) NIID, JAPAN ELDERLY A/NEW YORK/55/04 (H3N2) B/SHANGHAI/361/02 4. STEFAN GRAVENSTEIN, M.D. ADULTS A/NEW CALEDONIA/20/99 (H1N1) EASTERN VIRGINIA ELDERLY A/NEW YORK/55/04 (H3N2) MEDICAL SCHOOL, PEDIATRIC B/JIANGSU/10/03 USA 3

  4. ANTIGENS FOR SEROLOGIES (H3N2) VACCINE STRAIN A/New York/55/04 X-157 REPRESENTATIVE CURRENT STRAINS • A/Wisconsin/76/05 • A/Hiroshima/52/05 • A/Anhui/1239/05 • A/Brazil/1742/05 • A/North Carolina/13/05 • A/Sydney/545/05 • A/Lyon/21/06 • A/Norway/28/06 • A/Gunama/16/05 • A/Nagasaki/50/05 4

  5. HI ANTIBODY RESPONSES TO THE H3N2 COMPONENT2005-2006 INFLUENZA VACCINEPEDIATRIC POPULATION 5

  6. HI ANTIBODY RESPONSES TO THE H3N2 COMPONENT2005-2006 INFLUENZA VACCINEADULT POPULATION ( CBER ) 6

  7. A/NEW YORK/55/2004 VACCINESSUMMARY TABLE (ADULT)VIRUSES WITH > 50% GMT REDUCTION 7

  8. ANTIGENS FOR SEROLOGIES (B) VACCINE STRAIN B/JIANGSU/10/2003* REPRESENTATIVE CURRENT STRAINS B/FLORIDA/7/2004* B/KITAKYUSYU/5/2005* B/GANSU/9/2005* B/PHILIPPINES/1401/2005* B/MADAGASCAR/1509/2005* B/EGYPT/144/2005* B/MALAYSIA/2506/2004+B/OHIO/1/2005+ B/GUANGONG/321/2005+ B/ENGLAND/458/2005+ B/SINGAPORE/21/2005+ * B/YAMAGATA LINEAGE + B/VICTORIA LINEAGE 8

  9. HI ANTIBODY RESPONSES TO THE B COMPONENT2005-2006 INFLUENZA VACCINEPEDIATRIC POPULATION 9

  10. HI ANTIBODY RESPONSES TO THE B COMPONENT2005-2006 INFLUENZA VACCINEADULT POPULATION (CDC) 10

  11. B/JANGSU/10/2003-LIKE VACCINESSUMMARY TABLEVIRUSES WITH > 50% GMT REDUCTION (ADULT) 11

  12. Influenza Vaccine ResponsesSummary Studies with sera collected after immunization with current vaccines show that: • H1 • Representative recent viruses well inhibited (data not shown) • H3 • A/WISCONSIN/67/2005 (H3N2)-like viruses less well inhibited compared to the vaccine strain • B • B/YAMAGATA/16/88-lineage • Representative recent viruses generally well inhibited compared to the vaccine strain • B/VICTORIA/2/87-lineage • Representative B/Malaysia/2506/2004-like viruses poorly inhibited compared to the vaccine strain 12

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