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(1) Viral genome and reverse transcriptase enter cell.

Site of action of AZT and other reverse Transcriptase inhibitors. Host cell nucleus. Host cell genome. (7) Viral membrane proteins are transported to host cell membrane. (6) Viral RNAs are translated, yielding viral enzymes (including protease)

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(1) Viral genome and reverse transcriptase enter cell.

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  1. Site of action of AZT and other reverse Transcriptase inhibitors Host cell nucleus Host cell genome (7) Viral membrane proteins are transported to host cell membrane. (6) Viral RNAs are translated, yielding viral enzymes (including protease) and structural proteins. (4) DNA circularizes (unintegrated provirus) or integrase functions to incorporate DNA into host cell genome (integrated provirus). (5) With host cell activation, viral DNA is transcribed, yielding messenger RNAs and viral genome RNA. Site of action of protease inhibitors Site of action of antiretroviral drugs under development (1) Viral genome and reverse transcriptase enter cell. (8) Final viral assembly and budding take place. (2) DNA copy synthesized by reverse transcriptase. RNA DNA (3) RNA degraded; second DNA strand synthesized. DNA DNA

  2. (1) Viral genome and reverse transcriptase enter cell.

  3. Site of action of AZT and other reverse Transcriptase inhibitors (1) Viral genome and reverse transcriptase enter cell. (2) DNA copy synthesized by reverse transcriptase. RNA DNA

  4. Site of action of AZT and other reverse Transcriptase inhibitors (1) Viral genome and reverse transcriptase enter cell. (2) DNA copy synthesized by reverse transcriptase. RNA DNA (3) RNA degraded; second DNA strand synthesized. DNA DNA

  5. Site of action of AZT and other reverse Transcriptase inhibitors Host cell nucleus Host cell genome (4) DNA circularizes (unintegrated provirus) or integrase functions to incorporate DNA into host cell genome (integrated provirus). Site of action of antiretroviral drugs under development (1) Viral genome and reverse transcriptase enter cell. (2) DNA copy synthesized by reverse transcriptase. RNA DNA (3) RNA degraded; second DNA strand synthesized. DNA DNA

  6. Site of action of AZT and other reverse Transcriptase inhibitors Host cell nucleus Host cell genome (4) DNA circularizes (unintegrated provirus) or integrase functions to incorporate DNA into host cell genome (integrated provirus). (5) With host cell activation, viral DNA is transcribed, yielding messenger RNAs and viral genome RNA. Site of action of antiretroviral drugs under development (1) Viral genome and reverse transcriptase enter cell. (2) DNA copy synthesized by reverse transcriptase. RNA DNA (3) RNA degraded; second DNA strand synthesized. DNA DNA

  7. Site of action of AZT and other reverse Transcriptase inhibitors Host cell nucleus Host cell genome (6) Viral RNAs are translated, yielding viral enzymes (including protease) and structural proteins. (4) DNA circularizes (unintegrated provirus) or integrase functions to incorporate DNA into host cell genome (integrated provirus). (5) With host cell activation, viral DNA is transcribed, yielding messenger RNAs and viral genome RNA. Site of action of protease inhibitors Site of action of antiretroviral drugs under development (1) Viral genome and reverse transcriptase enter cell. (2) DNA copy synthesized by reverse transcriptase. RNA DNA (3) RNA degraded; second DNA strand synthesized. DNA DNA

  8. Site of action of AZT and other reverse Transcriptase inhibitors Host cell nucleus Host cell genome (7) Viral membrane proteins are transported to host cell membrane. (6) Viral RNAs are translated, yielding viral enzymes (including protease) and structural proteins. (4) DNA circularizes (unintegrated provirus) or integrase functions to incorporate DNA into host cell genome (integrated provirus). (5) With host cell activation, viral DNA is transcribed, yielding messenger RNAs and viral genome RNA. Site of action of protease inhibitors Site of action of antiretroviral drugs under development (1) Viral genome and reverse transcriptase enter cell. (2) DNA copy synthesized by reverse transcriptase. RNA DNA (3) RNA degraded; second DNA strand synthesized. DNA DNA

  9. Site of action of AZT and other reverse Transcriptase inhibitors Host cell nucleus Host cell genome (7) Viral membrane proteins are transported to host cell membrane. (6) Viral RNAs are translated, yielding viral enzymes (including protease) and structural proteins. (4) DNA circularizes (unintegrated provirus) or integrase functions to incorporate DNA into host cell genome (integrated provirus). (5) With host cell activation, viral DNA is transcribed, yielding messenger RNAs and viral genome RNA. Site of action of protease inhibitors Site of action of antiretroviral drugs under development (1) Viral genome and reverse transcriptase enter cell. (8) Final viral assembly and budding take place. (2) DNA copy synthesized by reverse transcriptase. RNA DNA (3) RNA degraded; second DNA strand synthesized. DNA DNA

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