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Presentation Transcript
43. Interazione tra CD 154 ectopica
e CD40 ancorato
45. Meccanismo TAX-dipendente
Proteina TAX del HTLV-1
?
Attivazione IKK chinasi
?
Attivazione NF-kB
Meccanismo TAX-indipendente
Degradazione di IkB?
51. Inibitori del proteosoma
Cinque classi diverse
Solo la classe peptide-boronato ha caratteristiche
che la rendono clinicamente utile
Utilità clinica
Caratteristiche
Stabilità metabolica, attività enzimatica, reversibilità del legame
56. Conclusioni Esiste il razionale patogenetico per l’uso degli inibitori del sistema NF-kB nelle malattie linfoproliferative
Attuale iniziale provata efficacia clinica del Velcade nella terapia delle malattie linfoproliferative
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