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CRPV (cotton-tail rabbit papillomaviruses)

CRPV (cotton-tail rabbit papillomaviruses). 報告者：洪晟綱 10067305. 老師：石麗仙老師. Virus function. CRPV induces cutaneous papillomas ( warts ) in cottontail rabbits and may cause keratinous carcinomas , typically on or near the animal’s head

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CRPV (cotton-tail rabbit papillomaviruses)

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  1. CRPV (cotton-tail rabbit papillomaviruses) 報告者：洪晟綱 10067305 老師：石麗仙老師

  2. Virus function • CRPV induces cutaneous papillomas (warts) in cottontail rabbits and may cause keratinous carcinomas, typically on or near the animal’s head • These tumors can become large enough that they interfere with the host’s ability to eat, eventually causing starvation • CRPV-associated carcinomas contain the viral DNA that is transcriptionally active, and the carcinogenic properties are believe to map to specific viral genes.

  3. Finder • Richard E Shope identified CRPV as the etiologic agent of cutaneous papillomatosis in rabbits. (1930) • Shope was able to isolate virus particles from tumors on captured animals and use these to inoculate domestic rabbits, which then developed similar tumors • Thus the virus is also called “Shope papilloma virus”

  4. Virus + external factors In the case of CRPV, carcinomas develop at an increased frequence in papillomas that are painted with cool tar or with MCA

  5. importance • The cottontail rabbit papillomavirus (CRPV)/rabbit model has proven to be the most versatile pre-clinical model to test antiviral, immunopotentiating and immunotherapeutic strategies for papilloma-virus infections. • Many of the treatments already tested in the CRPV/rabbit model have shown parallel efficacyagainst HPV infections in a clinical setting.

  6. bonus • The CRPV is also a possible source of myths about the jackalope • The jackalope is a mythical animal of North American folklore

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