1. a Fig.S2 3’UTR region 2-328 IGFBP2 3’UTR 5’ …CCCCUGUGUCCCUUUUGCAUAAG… hsa-miR-491-3p 3’ CAUCUUCCCUUAGAACGUAUUC IGFBP2 3’UTR-MT 5’ …CCCCUGUGUCCCUUUG… 3’UTR region 1-711 EGFR 3’UTR 5’ …ACUUUUGUAAAAAUGUCCCCACG… hsa-miR-491-5p 3’ GGAGUACCUUCCCAAGGGGUGA EGFR 3’UTR-MT 5’ …ACUUUUGUAAAAAUG G… 3’UTR region 8424-9167 CDK6 3’UTR F1 5’ …CCAAGAUGACCAACAUCCCCACA……CAUGUUCCUUAAAGGUGCAUAAU… has-miR-491-5p/3p 3’ GGAGUACCCUUCCAAGGGGUGA 3’ CAUCUUCCCUUAGAACGUAUUC CDK6 3’UTR F1MT 5’ …CCAAGAUGACCAACA A……CAUGUUCCUUAAAGGU… 3’UTR region 6434-7529 CDK6 3’UTR F3 5’ …AACGGGUGUCUUCUGUGCAUAAA……AAGUUGUUCUACAUUUGCAUAAA… hsa-miR-491-3p 3’ CAUCUUCCCUUAGAACGUAUUC 3’ CAUCUUCCCUUAGAACGUAUUC CDK6 3’UTR F3MT 5’ …AACGGGUGUCUUCUGA……AAGUUGUUCUACAUUA… b