1 / 7

Herz (Kleintier) PET

This study explores the challenges and advancements in molecular imaging, specifically focusing on the dopaminergic system in both human and mouse models of Parkinson's disease. By leveraging first-pass PET imaging techniques with radioactively labeled molecules, the research aims to enhance sensitivity and specificity in visualizing biological and medically significant molecules present in minimal quantities. The investigation includes the role of integrin αVβ3 in angiogenesis and its implications for cellular adhesion and migration, which is vital for understanding tumor biology and treatment responses.

meagan
Télécharger la présentation

Herz (Kleintier) PET

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Herz (Kleintier) PET

  2. Dopamintransporter Myokardstoffwechsel * Mensch ** * Maus ** Normal Parkinson ** Enddiastole, * Endsystole Striatum Harder Drüsen der Maus

  3. First-pass PET

  4. Herausforderungen Biologisch und medizinisch bedeutsame Moleküle liegen in minimalen Mengen vor (< 0.0001 Gramm pro Gramm Gewebe) Molekulare Bildgebung benötigt eine sehr hohe Empfindlichkeit Spezifität (keine Bindung an andere Moleküle) Aktuelles Verfahren in der Forschung und Klinik: Radioaktiv markierte Moleküle und Positronen-Emissions-Tomographie (PET) Molekulare Bildgebung

  5. a-chain Ca2+ b-chain Ca2+ S S Ca2+ talin a-actinin Structure and function of the v3 integrin • heterodimeric membraneprotein • expressed on activated endothelialcells and some tumor cells (melanoma, glioblastoma) • mediates cellular adhesion and migration during angiogenesis and metastasis formation • binds to an arginine, glycine, aspartate sequence (RGD) of matrix proteins

  6. Cyclic c(RGDfV) peptides bind specifically to the αVβ3, but not to related, RGD binding integrins Imaging the αVβ3 Integrin peptide integrin [nM] avb3 avb5 aIIbb3 c(RGDfV) 13 3,350 6,700 [I]Gluco-RGD 40 2,000 5,000 [F]Galacto-RGD 5 1,000 6,000

  7. Imaging the αVβ3 Integrin 64Cu-DOTA-RGD Delayed images (22 hours post injection) 7 U87 A431 %ID/g 0 CT PET fusion projection Ferl et al. J Nucl Med 2009

More Related