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HIV-related Research Overview

Dr. Steve Zeichner, a senior investigator at Children’s Research Institute, explores critical areas of HIV research, focusing on HIV virology, virus-host cell interactions, and the impact of viral genes on host cells. His studies analyze how cellular genes influence HIV latency and examine the basic virology of KSHV. Significant findings suggest that latently infected cells exhibit unique gene expression profiles, potentially guiding innovative strategies to manage HIV latency and advance therapeutic approaches in pediatric HIV disease.

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HIV-related Research Overview

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  1. HIV-related Research Overview Steve Zeichner, MD, PhD Sr. Investigator, Division of Cancer and Immunology Children’s Research Institute, Children’s National Medical Center Assoc. Prof., Dept of Pediatrics & Microbiology, GWUMC SZeichne@cnmc.org 202-884-6131

  2. Research Areas • HIV basic virology • Virus-host cell interactions • Effect of viral genes on the host cell • Cellular genes involved in the maintenance and control of HIV latency • KSHV basic virology • Control of KSHV gene expression • Clinical studies on pediatric HIV disease

  3. Effect of Vpr on Host Cell Gene Expression

  4. Models for Vpr-mediated Cell Cycle Arrest

  5. Hierarchical clustering of differentially expressed host cell genes before and after induction of lytic infection in ACH-2 cells.

  6. Conclusions • Latently infected cell lines show differences in cell gene expression compared to parental cells before lytic replication. • Agents targeting products of genes differentially expressed in latently infected cells can eject HIV from latency. • Such studies may suggest new ways of manipulating HIV latency, which might find clinical utility in studies aimed at assessing efficacy of reservoir reduction.

  7. Effect of the Viral DNA Replication Inhibitor Cidofovir On the Viral Gene Expression Pattern Color:- CDV Black: + CDV

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