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Parasympatholytic

Introduction of Parasympatholytics : M blockers: Atropine, Cyclopentolate , Scopolamine, Tropicamide N1 Blockers: Nicotine N2 Blockers: Tubocurarine , Atracurium. Parasympatholytic. Atropine Pharmaceutical chemistry Possible Origin Physiochemical Properties Idea of Retro-synthesis

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Parasympatholytic

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  1. Introduction of Parasympatholytics:M blockers: Atropine, Cyclopentolate, Scopolamine, TropicamideN1 Blockers: Nicotine N2 Blockers:Tubocurarine, Atracurium

  2. Parasympatholytic • Atropine • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: Anti-muscarinic • Structure-based explanation of Therapeutic uses: Mydriatic for measuring refractive errors of the eyes, (week-2 week duration). Replaced by short acting anti-cholinergics, Antispasmodic, anti-dote for mushroom poisoning and antisecretory. • Structure-based explanation of Side effects: dry mouth, blurred vision, Sandy eyes, tachycardia, constipation, restless and confusion. • Analysis

  3. Parasympatholytic • Cyclopentolate (Cyclogyl) • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: • Structure-based explanation of Therapeutic uses: short acting for mydriasis (24 hours) • Structure-based explanation of Side effects: • Analysis

  4. Parasympatholytic • Scopolamine • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: • Structure-based explanation of Therapeutic uses: motion sickness, block short-term memory and anti-spasmodic • Structure-based explanation of Side effects: • Analysis

  5. Parasympatholytic • Tropicamide (Mydriacyl) • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: • Structure-based explanation of Therapeutic uses: short acting for mydriasis (6 hours) • Structure-based explanation of Side effects: • Analysis

  6. Parasympatholytic • Nicotine (Nicotinell) • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: Ganglionic blocker (N2) • Structure-based explanation of Therapeutic uses: none • Structure-based explanation of Side effects: stimulation then paralysis of Ganglionic receptor, high blood pressure, increasing cardiac output, hypotension with high doses and low GI activity. • Analysis

  7. Parasympatholytic • Tubocurarine • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: Neuromuscular blocker (N1) • Structure-based explanation of Therapeutic uses: Adjuvant drug in anaesthesia to facilitate intubation. • Structure-based explanation of Side effects: it sometimes increases histamine release and causes hypotension (allergy). Thus it is rarely used. • Analysis

  8. Parasympatholytic • Atracurium (Tracrium) • Pharmaceutical chemistry • Possible Origin • Physiochemical Properties • Idea of Retro-synthesis • Molecular pharmacology • Mechanism of action: • Structure-based explanation of Therapeutic uses: • Structure-based explanation of Side effects: well-tolerated • Analysis

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