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The LCSES study examines the correlation between socioeconomic status (SES) and cardiovascular outcomes over the life course, incorporating historical and individual-level SES factors. Data collection includes childhood and adulthood SES information. The study aims to understand how neighborhood context influences the relationship between SES and cardiovascular events, exploring potential explanatory mechanisms. The questionnaire encompasses social exposures, military service, and place of residence, linking participants with census data. With a diverse cohort of over 12,000 individuals, LCSES investigates the intersection of SES and CVD outcomes, shedding light on the complex interplay of social determinants of health.
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Life Course Socioeconomic Status, Social Context and Cardiovascular Disease: The LCSES StudyKathryn Rose, PhDfor TheLCSES Study Team
LCSES and ARIC Studies • As part of the ARIC study, information on mid to later life socioeconomic status (SES) was collected at each of the four examinations • As an ancillary study, LCSES collected additional information from surviving participants about earlier life SES circumstances • Individual-level SES • Place of residence
LCSES Study Goals • Examine the association between SES across the life course and CVD-related outcomes • Determine the extent to which the current and historical (neighborhood) context modify the association of individual-level SES exposures and CVD events • Identify explanatory mechanisms for the SES-CVD association
LCSES Questionnaire • Administered during 2001-02 ARIC annual telephone follow-up (AFU) • 44 questions about childhood and earlier adulthood social exposures • Individual-level SES • Military Service • Place of residence • Used to link participants with historical census data
LCSES Participants • N = 12,716 • 80.5% of the baseline ARIC participants • Approximately 95% of cohort survivors
LCSES Participant Characteristics RACE/GENDER Black Women Black Men White Women White Men 16.5% 9.0% 40.8% 33.8% AGE at BASELINE 45-49 50-54 55-59 60-64 29.5% 27.3% 23.7% 19.7%
Type of Historical Data Collected Individual Level SES
Individual Level Childhood SES: • Mother and father’s (or other caretaker’s) • Education • Occupation • Census-based categories analogous to those used in ARIC study • Owner vs. worker • Whether or not managed or supervised • Home ownership
Recalled Individual-level SES-Related Attributes in Earlier Adulthood • Occupation at ages 30, 40, and 50 • Grouped into Bureau of Census Job Categories • Characteristics of Job • Owner vs. Worker • Managerial/Supervisory • Home ownership
Type of Historical Data Collected Contextual Level (Place of Residence)
Childhood Place of Residence • City / County / State of Residence during childhood • Data cleaning / editing • 3% resided outside of the US • 44% resided in the same county as in midlife • Linking with county-level census data • Chose decennial census (1930, 1940, 1950) that corresponded most closely to where participant livedat 10 years of age • Of the 12,314 participants who lived in the US as children, 99% were linked to county-level census data
Distribution of Participants by Birth Cohort 4000 3500 3000 2500 Number 2000 1500 1000 500 0 1921-25 1926-30 1931-35 1936-40 1941-45 ARIC Participant’s Birth Cohort
Place of Residence at Ages 30, 40, and 50 • Participants asked to provide their complete street address • Goal: link with census tract data from historical census (1960 – 1980) most closely corresponding to the given age • Only queried about address for a given age if not already in ARIC at this age
Progress to Data • Strategies for working with complex historical census data have been developed • Individual and contextual / neighborhood socio-economic exposure data across the life course has been assembled for study participants • Various research projects focusing on cardiovascular disease related outcomes are in progress