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Innovative Strategies for Combating Dengue and Insect-Borne Diseases through Genetic Approaches

Established in 2002, this Florida Keys-based foundation collaborates with entities like the USDA, Oxford University, and Institut Pasteur to tackle global challenges such as dengue fever. With a focus on reducing insect populations that transmit diseases, including Aedes aegypti, the foundation employs environmentally friendly strategies like Oxitec’s RIDL® technology. This approach aims to combat insect-borne diseases sustainably, enhance crop yields, and offer a reliable method to control invasive species. Join us in addressing the alarming rise of dengue cases worldwide.

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Innovative Strategies for Combating Dengue and Insect-Borne Diseases through Genetic Approaches

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  1. Florida Keys 15th March

  2. background • Foundation • Oxford University • 2002 • Private company, 40 staff • Collaborations • US Department of Agriculture • University of California, Irvine and Colorado State Univ • Institut Pasteur, France • Ministry of Health, Malaysia • Gorgas Institute, Panama • Mosquito Research and Control Unit, Cayman • GBIT, India • Moscamed / University of Sao Paulo Brazil • SIPPE China

  3. goals Combat insect borne diseases Improve crop yields through the reduction of the insect population causing disease or damaging crops genetic approach that is safe, sustainable, economic and applicable to many insect species worldwide

  4. dengue fever Dengue is a global unmet health challenge • 50 -100 million cases pa, increasing • One main vector worldwide; Aedes aegypti • Invasive species in most countries • Symptoms – joint/muscle pain ‘Breakbone fever’ • Severe form Dengue Haemorrhagic Fever (DHF) • No medication or vaccine • Same vector – Chikungunya and Yellow Fever

  5. reported dengue cases Sources: PAHO/WHO

  6. Why is dengue growing? • ‘Dengue prevention and control solely depends on effective vector control measures’ WHO • Aedes aegypti is an invasive species in most countries • highly adapted to the urban environment • very difficult to control with larvicides or insecticides • lays eggs in many small water containers • lives in and around the home

  7. RIDL® Oxitec’s solution

  8. sterile insect techniques • Benefits • environmentally friendly • males actively seek females • proven approach • long history • Major programmes • New World screw worm • Cotton (Pink bollworm) Citrus (Medfly) • But, has not proved viable in mosquitoes • Benefits • proven in mosquitoes • applicable to local area control • many species • minimal fitness penalty • male only release • ‘built in’ monitoring

  9. benefits of Oxitec’s approach • reduction in target insect population • species specific • self limiting strategy, controllable • defined area • low environmental impact • APHIS (USDA) Environmental Impact Statement: approach is ‘environmentally preferable’ to available alternatives.

  10. releases The releases are made at predetermined points by hand or from the back of a truck 1

  11. Cayman Islands open trial 2010 July- releases at target level August- popn starts to decline October- Control

  12. public engagement

  13. Thank you! www.oxitec.com

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