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Exploring the Impact of IGF-1, TNF-alpha, and gp130 on EPC Function in MNC Cultures

This research examines the effects of IGF-1, TNF-alpha, and gp130 signaling on endothelial progenitor cell (EPC) functionality within mononuclear cell (MNC) cultures. Utilizing various concentrations of IGF-1 and TNF-alpha, along with control groups, we analyze protein levels, specifically focusing on gp130 and LIFR expression. The study aims to elucidate the molecular mechanisms underlying EPC response to oxidative stress, as measured by tB-OOH levels, providing insights into potential therapeutic targets for vascular regeneration.

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Exploring the Impact of IGF-1, TNF-alpha, and gp130 on EPC Function in MNC Cultures

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  1. A B C D IGF-1 IGF-1 2000 1800 pg/mg protein 1600 TNFalpha E F 1400 gp130 LIFR CT+tB-OOH medium tB-OOH ** * Negative control MNC EPC

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