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The Complex Legacy of Thalidomide: From "Wonder Drug" to Cautionary Tale

Explore the history, risks, and current applications of thalidomide, a drug initially celebrated as a "wonder drug" for providing peaceful sleep. Synthesized in 1953, it was later linked to severe birth defects when used by pregnant women for morning sickness, leading to catastrophic outcomes and a 70% death rate for babies affected by its side effects. As thalidomide faces scrutiny, it has been reintroduced as a treatment for leprosy. This presentation examines its initial promise, the consequences of untested usage, and its modern-day applications.

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The Complex Legacy of Thalidomide: From "Wonder Drug" to Cautionary Tale

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  1. Human Life Terms PMS

  2. CDC CENTER OF DISEASE CONTROL

  3. FEDERAL AGENCY LOCATED IN ATLANTA, GEORGIA

  4. Highly SecureHome of the Bad of the Bad

  5. Ebola Dangerous viral disease Causes uncontrolled bleeding Has a 70% death rate

  6. Thalidomide GOOD OR BAD?

  7. FDA Mission Safe and Effective When used as directed

  8. Thalidomide – the sleeping pill

  9. Thalidomide was first synthesized in West Germany in 1953 by Chemie Grünenthal. • It was hailed as a "wonder drug" that provided a "safe, sound sleep".

  10. However the drug was also found to cure morning sickness in pregnant women

  11. Nausea vomiting in pregnancy NVP – 1st trimester ...(1/3)

  12. Foetal development - • The first few weeks are a key period – any problems now will accumulate in the future

  13. Nausea vomiting in pregnancy NVP – 1st trimester (1/3) • When do you think most women would be inclined to take this drug?

  14. Side effects • unfortunately molecules of the thalidomide chemical crossed the placenta and disrupt the growth patterns of the growing foetus

  15. Effect = catastrophic deformations of the baby– best seen as limb abnormalities.

  16. …if this was you – how would your life be different?

  17. Why did this happen? • Simple - the drug was not trialled or tested for this use on pregnant women

  18. Thalidomide today • Initially the drug was banned internationally for the treatment of morning sickness • But it has now been reintroduced as a treatment for leprosy

  19. Leprosy – bacterial infection of the skin and nerves endings • Affects the hands, feet and features of the face.

  20. Leprosy

  21. Make key notes on what we have discussed on this drug • Initial use • What it discovered to help • Side effects of untested use • What is it now used for

  22. This powerpoint was kindly donated to www.worldofteaching.com http://www.worldofteaching.com is home to over a thousand powerpoints submitted by teachers. This is a completely free site and requires no registration. Please visit and I hope it will help in your teaching.

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