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Best Infertility Hospital in Indore | IVF treatment cost in indore

Mohak infertility center is one of the best Infertility Hospitals in Indore, Mohak infertility center provides you best quality IVF treatment cost in indore with high success rate at affordable price. Our goal is to make your parenting dreams comes true. To Book an Appointment Now Call 78980-47572 / 80852-77666. For more detail visit www.mohakivf.com

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Best Infertility Hospital in Indore | IVF treatment cost in indore

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  1. MohakLaparoscopy and Infertility Center Cochrane Review

  2. Cochrane Review

  3. Question: Should we advise oral Inositol supplement in subfertile women with PCOS prior to infertility treatment? Focus:  OrALInositolsupplementATION versus no supplementATION or  folic ACID supplementATION prior to trEATMENT for infertility.1 Population of interest: Subfertile women with PCOS undergoing oVULATION induction or IVF. The MAJORITY of the TRIALS included women PLANNED for IVF, while few included women PLANNED for oVULATION induction. Intervention under investigation: OrALInositolsupplementATION  prior to infertility trEATMENT. Most of the studies included pretrEATMENT for up to 8-12 weeks prior to IVF. What was the comparison? No supplementATION or stANDARdsupplementATION (periconcEPTIONAL Folic ACID).

  4. What were the main outcomes? • Live birth, clinicALprEGNANCy AND miscARRIAGErATe. • Results in short: • Eleven  trials included 1472subfertile women with PCOS. Out of eleven TRIALS, nine involved PCOS women undergoing IVF. • Live birth rate: No difference in live birth rate with supplementation of oral Inositol vs. no supplementATION  in women undergoing IVF (OR 2.42,95% CI 0.75 to 7.83; P = 0.14; 2 RCTs; 84 women; very loW-QUALITY evidence). • Clinical pregnancy rate: No difference  in clinical pregnancy rates with  supplementation  of  oral  Inositol  vs. supplementATION   in women undergoing IVF (OR 1.27, 95%CI 0.87 to 1.85; P = 0.22; 4RCTs; 535 women; very loW-QUALITY evidence). • Miscarriage  rate:  Significantly  higher  miscarriage  rate  with supplementation  of  oral  inositol  vs.  no  supplementATION  in women undergoing IVF (OR 0.40, 95% CI 0.19 to 0.86; P = 0.02;4 RCTs; 535 women; I²= 66%; very loW-QUALITY evidence).

  5. Limitation: • No pooled evidence wAS AVAILABLE for women with PCOS undergoing oVULATION  induction, AS  only single TRIALS,  performed cOMPARING  of Inositol versus ClomiphenecitrATe or orAL insulin sensitising AGENTS, were included. • There wASclinicAL heterogeneity in pooled ANALYSIS due to vARIATION in the dose AND durATION of supplementATION of Inositol for IVF pretrEATMENT  . Most of TRIALS  used Myoinositol AND  doses vARIED from 550-4000 mgs AND durATION of supplementATIONvARIED from “first DAY of cycle to embryo trANSFer”  or upto six months prior to IVF. • The  controlled  ovARIANhyperSTIMULATION  protocols  (ANTAGONIST vs. AGONIST) used in the TRIALS were not reported. • None  of  the  TRIALS  in  the  IVF  pre-trEATMENT  group,  nor   in  the oVULATION  induction  group  reported  on  side  effects  rELATed  to myo-inositol.

  6. Evidence based practice points: Currently, there is uncertainty regarding role of routine Inositol supplementation in PCOS women undergoing IVF  with no difference being found in live birth or clinical pregnancy rates following Inositol supplementation versus no supplementation. Further, due to changing clinical practice towards more liberal use of “ freeze all” policy in PCOS women at high risk of OHSS, there may increased uncertainty about role of Inositol supplementation before IVF. There is also insufficient evidence for Inositolsupplemention in PCOS women undergoing ovulation induction due to paucity of trials. Further clarity on the role of Inositol would be possible only after high quality randomized trials evaluating its role  in  PCOS women for ovulation induction and IVF are available.

  7. Reference: 1. Showell  MG,  MACKenzie-Proctor  R,  JorDAN  V,  Hodgson  R,  FARQUHAR  C. Inositol for subfertile women with polycystic ovARY syndrome. CochrANE DATABASE Syst Rev. 2018, Issue 12: CD012378. Source: https://www.indianfertilitysociety.org/ifs-catalyst-cochrane-vol-5/ Mohak infertility center is one of the Best Infertility Hospital in Indore, Mohak infertility center provides you best quality IVF treatment cost in indore with high success rate at affordable price. Our goal is to make your parenting dreams comes true. To Book an Appointment Now Call 78980-47572 / 80852-77666. For more detail visit www.mohakivf.com

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