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Denis Nash, PhD, MPH Associate Professor Epidemiology and Biostatistics Program

Pre-amble: The promises and pitfalls of using assays for recent infection to estimate HIV incidence. Denis Nash, PhD, MPH Associate Professor Epidemiology and Biostatistics Program Hunter College School of Public Health SED Core, HIV Center for Clinical and Behavioral Studies.

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Denis Nash, PhD, MPH Associate Professor Epidemiology and Biostatistics Program

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  1. Pre-amble: The promises and pitfalls of using assays for recent infection to estimate HIV incidence Denis Nash, PhD, MPH Associate Professor Epidemiology and Biostatistics Program Hunter College School of Public Health SED Core, HIV Center for Clinical and Behavioral Studies

  2. A prospective study of HIV incidence HIV status unknown Recruitment

  3. A prospective study of HIV incidence Recruitment HIV testing HIV negative HIV positive

  4. A prospective study of HIV incidence Did not seroconvert Recruitment Seroconverted HIV testing Enrollment of HIV negatives Prospective follow-up HIV negative (study participants) Baseline 6 months Prospective follow-up HIV positive (excluded)

  5. A prospective study of HIV incidence Did not seroconvert Recruitment Seroconverted HIV testing Enrollment of HIV negatives Incidence rate = Prospective follow-up Person-time Calculation of HIV incidence Baseline 6 months Prospective follow-up HIV positive (excluded)

  6. A cross-sectional study of HIV incidence (STARHS) HIV status unknown Recruitment Baseline 6 months Retrospective follow-up

  7. A cross-sectional study of HIV incidence (STARHS) Seroconverted in last 6 months 1. Identification of HIV-positive persons via conventional HIV testing 2. Additional testing of HIV positives by recent Infection assay Seroconverted >6 months ago Baseline 6 months Retrospective follow-up

  8. A cross-sectional study of HIV incidence (STARHS) HIV-negative Seroconverted in last 6 months Incidence rate = Person-time Calculation of HIV incidence Seroconverted >6 months ago Excluded Baseline 6 months Retrospective follow-up

  9. Prospective study STARHS (cross-sectional) HIV-negative Did not seroconvert Seroconverted in last 6 months Seroconverted = Incidence rate = Incidence rate Person-time Person-time Seroconverted >6 months ago (excluded) Baseline Baseline 6 months 6 months Prospective follow-up Prospective follow-up HIV positive (excluded)

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