1. NATURAL PRODUCT CHEMISTRY TRI JOKO RAHARJO

2. Scopes • Introduction • Primary metabolism • Biosynthesis pyruvate • Biosynthesis shikimate • Lignin and lignan • Extension of phenil propanoate • Polyketide and Flavonoid • Terpenoid • Alkaloid • Isolation and Identification

3. Introduction • Primary and Secondary Metabolites • Primary Met: Essential molecules for survive of living things (protein, carbohydrate, DNA, lipid) • Secondary Met. : Molecules which are species specific with certain function • Asetyl-CoA (polyketide precursor) • Shikimic acid (aromatic precursor) • Mevalonic acid (terpenoid precursor) • Amino acid (precursor for peptide, alkaloid, pinicillin)

4. Introduction • Secondary Met. Characteristic and function • Species /genus/family specific • Certain function: respond to environment condition

5. Introduction • ASETYL-COA, Key intermediete

6. Primer Metabolism Process

7. Primer Metabolism Process • Primer metabolism related to plants: fotosynthesis

8. ASETYL-COA, Key intermediete Carbohydrate, protein lipid, DNA catabolism Asetyl-CoA anabolism Carbohydrate, protein lipid, DNA, Secondary Met.

9. ASETYL-COA, Key intermediete • MALONYL-COA, key partners for ASETIL-COA

10. ASETYL-COA, Key intermediete • HOW IS ASETIL-COA USED IN BIOSYNTHESIS • Fatty acid synthase (FAS) • Polyketide synthase (PKS)