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Pre-Pharmacy Society umdprepharm@gmail.com studentorg.umd.edu/ prepharm

Pre-Pharmacy Society umdprepharm@gmail.com studentorg.umd.edu/ prepharm. Get on the ListServ ...Join Our Facebook Group…Visit Our Website…CMNS Updates. 3 RD GENERAL BODY MEETING OCT . 24, 2011. Welcome! Don’t forget to sign-in Active Membership Requirements

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Pre-Pharmacy Society umdprepharm@gmail.com studentorg.umd.edu/ prepharm

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  1. Pre-Pharmacy Societyumdprepharm@gmail.comstudentorg.umd.edu/prepharm Get on the ListServ...Join Our Facebook Group…Visit Our Website…CMNS Updates 3RDGENERAL BODY MEETING OCT. 24, 2011

  2. Welcome! Don’t forget to sign-in • Active Membership Requirements • Community Service Opportunities • T-Shirt Contest & Fundraising Opportunity • Drug of the Week: TNF inhibitors • Pharmaceutical Issue: • Howard University COP Admissions presented by • NAME Agenda

  3. 3 Meetings per semester • 3 Hours of Community Service per semester • Please do not wait until till the end of the semester to fulfill your community service hours • Exceptions will not be made Active Membership Requirements

  4. Off-Campus Community Service Events

  5. DC Central KitchenTuesday, November 8th 2011 13 people can sign-up!!! Please bring money for the MetroLeave from ATM outside of Stamp @ 3:55 pm Dress Code: Wear long pants (no pajama pants, no spandex pants, please) Closed-toed shoes Shirts with sleeves (short sleeves are okay, tank tops are not) A hat or other head covering (hairnets are provided) Midriff shirts are not allowed Volunteer activities include chopping, sorting and vacuum-sealing fresh produce that we get from local farms; mixing salads; portioning meals; de-boning meat; baking healthy snacks; and sorting cans. http://combatinghunger.org/volunteer/Register/index.php

  6. Bake Sale Fundraiser • Counts as 1 hour for on campus service: • Bring individually wrapped baked goods (enough to serve at least 10) • Sign up for 1 hour block to help sell baked goods. • When: • November 7th from 10am-2pm • Where: • Outside STAMP (near the Capitol One ATM) Community Service Events

  7. Please send all ideas to Long at • LLA@terpmail.umd.edu • It’s easier said than done- don’t send an idea, but create the shirt on websites such as customink.com • More colors means it will be more expensive so try to be conservative, but creative • Winner will get the shirt for free! • **The Maryland Terrapin is not allowed to be on it T-Shirt Design Contest!!!

  8. Each card is valid for one year or longer in participating Papa John’s restaurants in DC, Maryland and Virginia. • $15 per card • Cardholders are eligible to buy any amount of pizzas at menu price and receive an equal amount free • Whoever sells the most tickets will receive a free T-shirt! Papa John’s Fundraiser

  9. Drug of the Week Tumor necrosis factor (TNF) inhibitors

  10. Tumor necrosis factors (TNF) are a family of cytokines that are secreted during the immune response. • Specifically, TNF-α is a potent pyrogen involved in systemic inflammatory response produced by activated macrophages. Tumor necrosis factors

  11. TNF can cause many of clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosingspondylitis, Crohn’s disease, and refractory asthma. • The mode of action of TNF inhibition is accomplished via the blockage of Tumor necrosis factor from binding to its receptor, eliminating abnormal B cell activity. TNF Inhibitors

  12. Infliximab (Remicade) • Adalimumab (Humira) • Certolizumabpegol (Cimzia) • Golimumab (Simponi) • Etanercept (Enbrel) • Xanthine derivatives (e.g. pentoxifylline) • Bupropion Examples of TNF Inhibitors

  13. Skin disease – Treatment of inflammatory skin diseases. • Rheumatoid arthitis – Based on recognition of the role of TNF-alpha as the “master regulator” of the inflammatory response in many organ systems. Applications

  14. Side effects can include: • Lymphoma • Infections • Congestive heart failure • Demyelinating disease • Lupus-like syndrome • Induction of auto-antibodies • Injection site reactions • Systemic side effects Side Effects

  15. Scheinfeld N. A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab. J Dermatolog Treat. 2004;15:280-294 • Brustolim D, Ribeiro-dos-Santos R, Kast RE, Altschuler EL, Soares MB (June 2006). "A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice". Int. Immunopharmacol.6 (6): 903–7. • Gómez-Reino, J. J., Carmona, L., Valverde, V. R., Mola, E. M., and M. D. Montero. Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: A multicenter active-surveillance report. Arthitis & Rheumatism. 48 (8): 2122-2127). Sources

  16. Pharmaceutical Issue MARYLAND passes the Prescription Drug Monitoring Program - May 2011

  17. Focuses on potentially addictive prescription drug • Recognizing trends indicating drug abuse • Database set up to register prescriptions when they are filled. • Doctors and pharmacists will be able to track who is getting prescription drugs and whether or not they have more than one prescription for the same drug. Overview…

  18. 2006 - passed the legislator but stalled in the Governor’s office. • 2011 - Governor O’Malley backed the Senate version of the bill. • passed the Senate • passed the House by a 121-15 margin • Maryland – 47th State to pass the bill • Effective – October 2011 Legislation…

  19. http://www.youtube.com/watch?v=Bb4evqsUP38 News Video…

  20. “…Our new program will link public health and public safety systems to knock down the silos that currently block information-sharing and provide the knowledge that is essential to the health and well-being of the people of our state." Governor O'Malley Purpose…

  21. GAO noted that PDMP increased diversion of prescription drugs in surrounding states without PDMP’s. • “Studies show that the effectiveness of PDMPs for impacting prescription drug abuse is related to ensuring that data are accurate and up-to-date and that users of the PDMP database perceive this to be the case.” Bureau of Justice Assistance…

  22. Impact on physicians changing their prescription practices: • “the PDMP did not appear to change practices; indicating that those in need of strong prescription drugs actually receive them.” • “only a small number of respondents indicated that being closely monitored by the PDMP has changed their prescribing practices in such a way that it has negatively impacted their ability to help patients with pain management.” Continued…

  23. Privacy concerns may hinder evaluation of PDMPs. • Variations in PDMPs among states may cause challenges with cross-state comparisons. • Poorly designed PDMP databases may increase the likelihood that legitimate cases of prescription drug use are included in the data analyses. Program Evaluation

  24. Recognize trends in potential drug abuse • Track “pill mills” • Increase speed of investigations of drug abuse • Lower number of deaths from drug abuse • Being mindful of patients with real chronic pain Pros…

  25. Cons… • Unwarranted intrusion by government in peoples medical life • Underutilization of the program • Patient’s fear in obtaining a prescription for a drug that is targeted abusive (potential) • Cost - approximately $500,000/year without private grants • Possibility of having direct access of drugs from doctor

  26. Will the bill unintentionally give rise to illegal access of drugs from overseas? • What are some ethical concerns that prescribers may face in issuing a prescription? • How can prescribers differentiate between a potential drug abuser from another? • What are some concerns that may arise for lower income patients with this program? • How can the states maintain the program’s efficiency in meeting the goal? Issues to consider…

  27. http://www.dhmh.maryland.gov/pressreleases/2011/gov051011.htmlhttp://www.dhmh.maryland.gov/pressreleases/2011/gov051011.html • http://knowledgebase.findlaw.com/kb/2011/Aug/395387.html • http://articles.orlandosentinel.com/2011-02-24/news/os-prescription-drug-monitoring-20110224_1_narcotics-overdose-prevention-pill-mills-pain-pill • http://www.homehealthtesting.com/blog/2011/04/pill-mills/ • http://www.ojp.usdoj.gov/BJA/evaluation/program-substance-abuse/pdmp2.htm References…

  28. Pre-Pharmacy Society Proudly Presents… Name, Title Howard University College of Pharmacy Admissions

  29. THE END! THE END! Pre-Pharmacy Societyumdprepharm@gmail.comstudentorg.umd.edu/prepharm Get on the ListServ...Join Our Facebook Group…Visit Our Website…CMNS Updates THE END! THE END! 3RDGENERAL BODY MEETING OCT. 24, 2011

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