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Epigenetic Modulations in Brain, Liver, and Muscle: Analyzing Acetylation and Methylation Patterns

This study explores the intricate epigenetic mechanisms of acetylation and methylation across brain, liver, and muscle tissues. We focus on the active and inactive states of histone modifications, with particular attention to MeCP2 and various acetylation sites. Insights into CpG islands and the roles of HDAC and HAT are discussed in the context of gene regulation and demethylation processes. This research contributes to understanding the temporal dynamics of epigenetic regulation during cellular replication cycles.

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Epigenetic Modulations in Brain, Liver, and Muscle: Analyzing Acetylation and Methylation Patterns

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  1. CTGAGTC

  2. Brain Liver Muscle

  3. CpG Island

  4. Ac Ac Ac Active Inactive

  5. Ac MeCP2 Ac

  6. GC GC CG CG CG CG GC GC GC GC CG CG

  7. Brain Liver Muscle

  8. m C m C A A C C T T G G p 5 3 - / - p 5 3 - / - M T a s e - / -

  9. Ac Ac Ac HAT

  10. Ac Ac Ac HAT

  11. Ac Ac Ac HDAC HAT

  12. HDAC HAT

  13. I B I B III 4 Me Ac 4 Demethylation H3 H4 H4 H3 Me 9 9 Me Ac

  14. Demethylation

  15. 104 I Non e 101 II Repressor 102 II I M e M e 10-1 I V +

  16. M S G2 G1 3 h 5 h 7 h 9 h 11 h G2 M S G1

  17. M G2 G1 S Replication time

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