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Maximizing Your Research Potential

Maximizing Your Research Potential. William D. Snyder CTP. Why Research?. CMS measurement (0.22 research organs per donor) Inherently flawed measurement in light of increasing OTPD Study of disease processes subsequent treatment for diseases that can land people on the transplant list

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Maximizing Your Research Potential

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  1. Maximizing Your Research Potential William D. Snyder CTP

  2. Why Research? • CMS measurement (0.22 research organs per donor) • Inherently flawed measurement in light of increasing OTPD • Study of disease processes • subsequent treatment for diseases that can land people on the transplant list • Unique opportunity • living cells that are crucial for researchers • Provide Control group • Honoring the donor’s wishes

  3. People who need answers through research? 2 million Type 1 diabetics 15 million with Asthma 40,000 with Cystic Fibrosis 3.2 million with Hepatitis C

  4. Research Organs Placed/Donor2011-2012

  5. Small changes for immediate results Call early Most successful OPO’s start at time of allocation Back up everything intended for transplant Surgical Staff (1 point person) for placement and recovery Consistent communication Familiar with recovery protocol Relationship with researcher Cost savings Create your own research projects (Biopsy Comparison?)

  6. Building Research Opportunities • Build working relationships with your academic/ research community • Research placement/ recovery position? • Success lies in motivation! • Create your own IRB and Application Process • Adding a link to this on your website • Networking with your transplant physicians • Options for-profit/ non-profit • Keep lists, numbers, criteria current and readily accessible • Work close with your Medical Examiner / Coroner

  7. Current Research Projects • Heart’s (from 1 researcher) • construction of cardiac atlas, application to create pt specific models to provide insight into ventricular arrhythmias, atrial fib, and CHF • Study of Kawasaki Disease ( specifically, coronary artery dilation) • Our pediatric hearts were the control for this study • Mechanics of Aortic Valve Calcification • Creation of bio-engineered gel for regeneration of myocardial cells

  8. Current Research Projects • Lungs, study the genes that are the signal pathway in pulmonary hypertension • Looks at the Notch 3 and Hef-5 gene that are turned on in pulmonary hypertension disease process • Goal is to design inhibitors for this gene w/ collaboration from local bio-tech company • Again, our lungs are the control

  9. Pancreata- • Npod study • islet cells • Intestines/Stomach- • medication coatings • medical absorption • Kidneys- • development of preservation machines/ fluids • Other- • DRG’s • Brains Current Research Projects Continued… Hearts- myocardium stem cells aortic valve disease Lungs- treatment of cystic fibrosis asthma medication anthrax inhalation intervention Livers- hepatocytes medication toxcicity

  10. THANK YOU!

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