Global Impact of Metal Treatment on Gene Regulation Across COG Functional Classes

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This study examines how metal treatment, specifically exposure to Zinc and Cadmium, influences gene regulation in isolates STM 2683 and STM 4661, classified by COG functional categories. Box plots illustrate the log2-transformed ratios of read numbers from metal-treated versus control samples for various COG classes (C to V). The analysis reveals significant changes, particularly in class J, where approximately 75% of the data shows a negative log2-fold change. Outliers and extreme values are highlighted to emphasize the variability in gene expression responses to metal exposure.

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May 02, 2026

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Global Impact of Metal Treatment on Gene Regulation Across COG Functional Classes

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Additional file 9:Global effect of metal treatment on the regulation of genes as classified by COG functional categories. Box plots representing the distributions of the log 2-transformed ratios of read numbers from the metal treatments per read numbers from control treatments, for CDS assigned to COG classes C to V (indicated at the bottom of each graph), for isolate STM 2683 (A and B) or STM 4661 (C and D) upon Zinc (A and C) or Cadmium (B and D) exposure. When within the scale, circles correspond to outliers and asterisks to extreme outliers and the blue color indicate extreme values. Black lanes and red crosses within boxes correspond to the median and average values respectively. Note that approximately 75 % of the data from class J (labeled in red) present a negative log 2-fold change.

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