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Successful Management of Extra-Gonadal Germ Cell Tumor in Young Adult: A Case Study

This case study outlines the clinical journey of a 25-year-old single male diagnosed with an extra-gonadal germ cell tumor identified as embryonal carcinoma. Initially presenting with weight loss, fever, and night sweats, he underwent imaging and tumor marker evaluation leading to chemotherapy with EP (Etoposide and Cisplatin) and subsequent surgical intervention. Post-operative complications included intrahepatic thrombosis and possible compartment syndrome. Intensive multidisciplinary care facilitated his recovery, culminating in a return to normal activities with no evidence of residual tumor.

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Successful Management of Extra-Gonadal Germ Cell Tumor in Young Adult: A Case Study

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  1. CASE STUDYKaren Fitzmaurice Urology Cancer Coordinator Tallaght Hospital

  2. 25 yr old single man No PMX of note Sept 2012 generally unwell Weight loss Fever Night sweats Seen by GP CT – large retroperitoneal mass 15 x 12 x 11cms Referred to Oncology Presentation

  3. Tumour Markers AFP – 1.0 (0 - 5.0) HCG – 6.2 (<5 ) LDH – 2475 (100 - 350) Testicular exam - NAD Bx. of mass – extra gonadal germ cell tumour – embryonal carcinoma. Sperm banking attempted - no sperm seen Presentation

  4. Treatment • 4 cycles EP (Etoposide & Cysplatin) • Complicated by intrahepatic thrombosis of the IVC • Commenced Clexane • CT - mass reduced in size to 5.2 x 4.2 x 3.7 cms • Referred to Mr Thornhill

  5. Surgery • Extensive RPLND on 24/05/2013 - mass was densely adherent and required an arterial graft from aorta to the right iliac artery. • Operating time 8 ½ hours • EBL= 3,600mls • Developed right leg ischemia in the recovery room & returned to theatre

  6. Significant amount of thrombus recovered Transferred to ICU Exploration of graft with popliteal & pedal embolectomy

  7. 1ST Day Post Op • Developed right leg pain & reduced ankle movement. • Possible compartment syndrome (increased pressure within a muscle compartment) • Patients are at higher risk of compartment syndrome when a blood vessel is damaged & subsequently repaired through surgery.

  8. Right Calf Fasciotomy

  9. Closure of medial fasciotomy &VAC dressing to lateral fasciotomy 27/05/13

  10. MDT – nursing & medical staff, dietician, physiotherapy, Pain team, occupational health, discharge planning. PCEA TPN NPO, N/G, central line U/C Clips & tension sutures Heparin x 7 days then clexane 6/7 ICU Weight bear 3/7 post op Exercises - prevent foot drop Resting calf splint Mobilising frame 2/52 post op. Vac dressing x 15 days Occupational health home visit Discharged on 12/06/13 Post Operative care

  11. Discharge • Convalescence x 1/52 • Community physiotherapy • 24/07/13 seen in clinic for histology results – no evidence of residual viable tumour. • D/C from urology to oncology. • October 2013 – resumed normal activity i.e. swimming & cycling. • Continues to attend physiotherapy sessions.

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