1 / 16

Epidemiology and clinical relevance

Epidemiology and clinical relevance. 1. World (thousands) cases: 204 Deaths 125 Europe cases: 63 Deaths 40. 2. Age standardized mortality rates, UE. _____ all ages ………35-64 years. La Vecchia et al, Ann Oncol 2010. 3.

nijole
Télécharger la présentation

Epidemiology and clinical relevance

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Epidemiology and clinical relevance 1

  2. World (thousands) cases: 204 Deaths 125 Europe cases: 63 Deaths 40 2

  3. Age standardized mortality rates, UE _____ all ages ………35-64 years La Vecchia et al, Ann Oncol 2010 3

  4. Temporal trends of incidence and mortality rates, Italy AIRTUM, Epidemiologia e prevenzione 2006 4

  5. Incidence and mortality rates in strata of age, Italy AIRTUM, Epidemiologia e prevenzione 2006 5

  6. 6

  7. Serous 40 percent of all ovarian cancers; most common ovarian cancer Endometrioid 20 percent of all ovarian cancers; 15 percent of endometrioid carcinomas coexist with endometriosis; 40 percent bilateral Mucinous 25 percent of all ovarian cancers; origin unclear; may occur in association with endometriosis; associated with pseudomyxoma peritonei

  8. Decreased risk Early menopause/late menarche Multiparity Hysterectomy Low-fat diet Oral contraceptive use Main factors associated with ovarian cancer risk Increased risk Early menarche/late menopause Endometriosis Estrogen replacement therapy Family history Genetic syndromes High-fat diet Low parity

  9. 9

  10. HRT use and hystologic subtypes 10

  11. Published studies on the relation between fertility treatments and ovarian cancer risk Ron et al., 1987 Shu et al., 1989 Brinton et al., 1989 Whittemore et al., 1992 Harris et al., 1992 Rossing et al., 1994 Risch et al., 1994 Franceschi et al., 1994 Venn et al., 1995 Purdie et al., 1995 Shushan et al., 1996 Parazzini et al., 1997 Mosgaard et al., 1997 Glud et al., 1998 Modan et al., 1998 Nugent et al., 1998 Cramer et al., 1998 Parazzini et al., 1998 Potashnik et al., 1999 Venn et al., 1999 Klip et al., 2000 Ness et al., 2000 Parazzini et al., 2001 Goodman et al., 2001 Ness et al., 2002 Lerner geva 2010 11

  12. Fertility treatments od risk of ovarian cancer Casi Controlli N. % N. % OR (95% CI) Total No 1016 98.5% 2385 98.9% 1.0 yes 15 1.5% 26 1.1% 1.3 (0.7-2.5) Nulliparae No 181 98.4% 370 97.1% 1.0 Yes 3 1.6% 11 2.9% 0.6 (0.1-2.0) Parae No 835 98.6% 2015 99.3% 1.0 Yes 12 1.4% 15 0.7% 1.9 (0.9-4.1) Parazzini et al., 2001 12

  13. Cases Controls Adj OR 95% C.I. Clomiphene No 892 1070 1.0 1-3 m 17 25 0.9 (0.5 - 1.7) 4-12 16 29 0.8 (0.4 - 1.4) > 12 9 10 1.2 (0.5 - 3.0) Gonadotropin No 916 1110 1.0 1-3m 10 10 1.5 (0.6 - 3.6) 4-12 6 13 0.6 (0.2 - 1.6) > 12 3 1 4.5 (0.5 - 44.1) Ness et al., 2002 13

  14. Incidence of ovarian cancer among patents with endometrioiss and the general Swedish population (Melin et al, 2006) 14

  15. Diet and ovarian cancer • Cases-controls studies have shown a positive association between fat consumption and risk of ovarian cancer • Cases-controls studies have shown a negative association between fat vitamin A,C, E and risk of ovarian cancer • The women Health Initiative Dietary Modification Randomized Controlled Study has shown a decreased risk of ovarian cancer after 4 years of low fat diet(Prentice et al, 2007) 15

  16. grazie 16

More Related