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Human Subventricular Zone: From Neural Stem Cells to Gliomas

Human Subventricular Zone: From Neural Stem Cells to Gliomas. Bowen Jiang February 17, 2010.

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Human Subventricular Zone: From Neural Stem Cells to Gliomas

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  1. Human Subventricular Zone: From Neural Stem Cells to Gliomas Bowen Jiang February 17, 2010

  2. “In adult centers the nerve paths are something fixed, ended, immutable. Everything may die, nothing may be regenerated. It is for the science of the future to change, if possible, this harsh decree” -Santiago Ramon y Cajal

  3. What is it? Sanai et al. Nature 2004

  4. Where is it? Sanai et al. Nature 2004

  5. What’s in it? • Ciliated Ependymal Cells (Type E) • Proliferating Neuroblasts (Type A) • Slow Proliferating Cells (Type B) • Actively Proliferating Cells or Transit Amplifying Progenitors (Type C)

  6. Quinones-Hinojosa et al. Neuron 2006

  7. Quinones-Hinojosa et al. Neuron 2006

  8. Brain Tumor Each year, approximately 61,000 people in the United States are given a new diagnosis of a brain tumor, 80% of which have either a high-grade glioma or metastatic tumor, conditions with very poor long term survival. Brain tumors are the leading cause of solid tumor cancer death in children under the age of 20. It is estimated that 360,000 people in the United States are living with the diagnosis of a primary brain tumor.

  9. Types of Brain Tumor: Glioma • Glioma – CNS tumor arising from glial cells • Ependymomas – ependymal cells • Oligodendrogliomas – oligodendrocytes • Astrocytomas – astrocytes • Glioblastoma multiforme (mixed) • Astrocytes and oligodendrocytes

  10. Neural Stem Cells/Tumor

  11. Future Implications • BTSCs may play a role in maintaining bulk of glioma tumor • Understand BTSC origin and function, as well as role of human SVC, may lead to new therapeutic strategies • Label SVC NSC and follow recruitment to intracranial glioma (potential)

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