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Post-Column Infusion Ion Suppression Analysis of Anticoagulants in Serum Samples

This study presents experimental data on post-column infusion ion suppression, using a solution of analytes and internal standards at 10 mg/L. A syringe infusion (10 µL/min) allows for the analysis of typical extracted ion chromatograms for a precipitated blank serum sample and a solvent blank. The chromatograms depict retention times for various anticoagulants, including Dabigatran, Edoxaban, and Rivaroxaban, alongside their respective 13C6 isotopologues, illustrating relative abundances across different time points.

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Post-Column Infusion Ion Suppression Analysis of Anticoagulants in Serum Samples

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  1. Supplemental Digital Content 3.Typical post-column infusion ion suppression experimental data, collected whilst a solution of all analytes and internal standards (each 10 mg/L) was infused post-column via a syringe (10µL/min). Shown are representative extracted ion chromatograms (± 5 ppm window) of a precipitated blank serum sample (grey trace) and a solvent blank (black trace). Overlaid are chromatograms to illustrate the retention times of the analytes. Dabigatran Dabigatran-13C6 Rivaroxaban-13C6 Rivaroxaban Relative Abundance (%) Edoxaban Apixaban 0.0 2.0 0.0 1.0 2.0 3.0 1.0 3.0 Time (min)

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