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Integration of Metabolism Chapter 27

Integration of Metabolism Chapter 27. Regulatory Themes. Allosteric interactions Covalent modification Adjustment of enzyme levels Compartmentalization Metabolic Specialization of Organs. Control sites. Glycolysis. Control sites. Citric Acid Cycle/Oxidative Phosphorylation

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Integration of Metabolism Chapter 27

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  1. Integration of MetabolismChapter 27

  2. Regulatory Themes • Allosteric interactions • Covalent modification • Adjustment of enzyme levels • Compartmentalization • Metabolic Specialization of Organs

  3. Control sites • Glycolysis

  4. Control sites • Citric Acid Cycle/Oxidative Phosphorylation • ATP and respiratory control • Pyruvate Dehydrogenase

  5. Control sites • Gluconeogenesis and Pentose Phosphate pathway • PPP and NADPH for reductive biochemistry • F-1,6-Bis phosphatase

  6. Control sites • Glycogen Synthesis/Breakdown • Reciprocal hormone regulation

  7. Control sites • Fatty Acid Synthesis • Citrate • Malonyl CoA and carnitine

  8. Key Junctions in Metabolism

  9. Glucose-6-phosphate

  10. Pyruvate and Acetyl CoA

  11. Metabolic Organ Profiles

  12. Relations between organs Sugars and proteins

  13. Lipid Metabolism

  14. Starvation !!!

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