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Myeloid cells matter

Myeloid cells matter. Conclusions. Joshua Anzigen : . HIV. Glut1+ CD14++ CD16+ Associated with inflammatory markers. Immune activation HIV- related diseases. Intermediate monocytes are possible markers to identify HIV-infected subjects at risk for HIV-1 related co-morbidities.

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Myeloid cells matter

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  1. Myeloid cells matter Conclusions

  2. Joshua Anzigen: HIV Glut1+ CD14++ CD16+ Associated with inflammatory markers Immune activation HIV-relateddiseases Intermediate monocytes are possible markers to identify HIV-infected subjects at risk for HIV-1 related co-morbidities

  3. Francesca Graziano: Purging the HIV reservoir ? HAART ATP ATP stimulation of Mφ Adapted from M. Stevenson, NatMed. 2003 Extracellularvirion release Intracellularvirionsaccumulation

  4. Maria Isabel Sade-Ovalle: Blocking antibodies Tim3-Gal9 T cell-Mφinteraction modulation of cytokines release from T cells and Mφ Control of M.tb. growth in HIV patients ? Favor HIV entry Favor HIV-specific T cellresponses Modulation of the Tim3-Gal9 pathway favor antimicrobial immunity against Mycobacterium tuberculosis

  5. Tran Huyen: In TB – HIV coinfection Alteration of pro/anti inflammatory genes and modulation of the complement system in monocytes Identify specific signatures prognostic for development of TB-IRIS Monocytes contribute to the development of TB-IRIS

  6. Myeloid cells matter Reservoir of HIV Non-communicable diseases Dysregulation of Metabolic pathways HIV-related dementia Opportunistic infections IRIS

  7. Points for discussion • Immune activationdrivesdiseaseprogression. • Classical (CD14+CD16-) vs non classical (CD14+/CD16+) monocytes: whatistheirrole in immune activation? • Increasedlevel of blood non classicalmonocytesiscorrelated with diseaseprogression. Non classicalM-DC8+ monocytes accumulate in the peripheralblood of viremicuntreatedpatients (Dutertre et al. 2013). • Betterdefinition of monocyte/macrophages and DC subsets in severalanatomicalcompartment…and theirroleasviralreservoirs. • Focus on alternative approaches to purge HIV reservoirs.

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