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*Center of Excellence Influenza Research and Surveillance

In April 2007, the University of Rochester was awarded from NIAID a 7 year contract to create the New York Influenza Center of Excellence(NYICE). Welcome to the NYICE Year 5 Kickoff!.

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*Center of Excellence Influenza Research and Surveillance

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  1. In April 2007, the University of Rochester was awarded from NIAID a 7 year contract to create the New York Influenza Center of Excellence(NYICE). Welcome to the NYICE Year 5 Kickoff! The New York Influenza Center of Excellence (NYICE) is one of 5 centers that make up the NIAID CEIRS* Network *Center of Excellence Influenza Research and Surveillance Contract: HHSN266200700008C

  2. The National Institute of Allergy and Infectious Diseases (NIAID) in April 207 funded a 7-year plan to six “Centers of Excellence for Influenza Research and Surveillance” (CEIRS) at universities and other institutions from New York City to Los Angeles. “The goal of the newly created centers is to provide the federal government with important information to inform public health strategies for controlling and lessening the impact of seasonal influenza as well as an influenza pandemic,” - NIAID Research under the NIAID contracts ranges from monitoring of Americans’ responses to flu vaccination to identification of possible targets for new antiviral drugs and testing of pigs and wild birds. Each center collaborates with a number of other agencies and institutions. The initiative builds on a program launched by the NIAID after the original human outbreak of H5N1 avian flu in Hong Kong in 1997. Contract: HHSN266200700008C

  3. KICKOFF Contract Year 5 April 1, 2011 – march 31, 2012

  4. In this presentation, we will cover what the NYICE has accomplished in Years 1-4 (2007-2011), the current checkpoint, and goals for Years 5-7 (2011-2014) of the contract Agenda • Past Recap of the past 4 Years • NYICE accomplishments • Present Current Status – April 2011 • Where we are today • Future Goals - Next 3 Years

  5. Let’s start with the Year 1 – 4 of the contract… PAST 4 Years April 1, 2007 – March 31, 2011 NYICE accomplishments…

  6. 1 PAST NYICE accomplishments Year Apr 2007 – Mar 2008 • Contract awarded 7 year, $26 million NYICE contract • The NYICE established and the team assembled • DMID 07-0043 College Student Surveillance Study – Start • DMID 07-0046 Family Surveillance Study – Start • DMID 07-0090 Healthy Donor Study – Start • Project 1, 2, 3, 4, 5 Pilot/Supplements - Start • Data Management - Start

  7. 2 PAST NYICE accomplishments Year Apr 2008 – Mar 2009 • DMID 07-0043 College Student Surveillance Study – Continue • DMID 07-0046 Family Surveillance Study – Continue • DMID 07-0090 Healthy Donor Study – Continue • Projects 1, 2, 3, 4, 5, Pilots/Supplements – Continue • Data Management - Continue • # Publications - 1

  8. 3 PAST NYICE accomplishments Year Apr 2009 – Mar 2010 H1N1 Pandemic • External Advisory Committee • DMID 07-0043 College Student Surveillance Study – Continue • DMID 07-0046 Family Surveillance Study – Continue • DMID 07-0090 Healthy Donor Study – Continue • Projects 1, 2, 3, 4, 5, Pilots/Supplements – Continue • Data Management - Continue • DMID 09-0034 Acute Flu Study - Start • # Publications – 2

  9. Much has been accomplished with your support 4 PAST NYICE accomplishments Year • Host the 4th Annual CEIRS Network Meeting Apr 2010 – Mar 2011 • DMID 07-0046 Family Surveillance Study – Continue • DMID 07-0043 College Student Surveillance Study – Continue • DMID 07-0090 Healthy Donor Study – Continue • Projects 1, 2, 3, 4, 5, Pilots/Supplements – Continue • Data Management - Continue • DMID 10-0011 Inactivated Assessment to Inactivated Vaccine for • Novel H1N1 Virus – Start / Complete • DMID 08-0059 H5 Revax Study - Start • DMID 09-0085 Pregnancy PBMC Study - Start • ImmPort – Upload data associated with publications - Start • Projects – Continue • # Publications – 10

  10. We have come a long way. To summarize… PRESENT April 2011 Where we stand checkpoint…

  11. PRESENT Current Status Studies are in place and the Vaccine Research Unit collects blood for the NYICE research April 2011 Timeline Current Contract Year 1 2 3 4 5 6 7 The Specimen Processing Lab processes and stores the specimens for the research DMID 07-0043 College Student Surveillance Study DMID 07-0046 Family Surveillance Study DMID 07-0090 Healthy Donor Study DMID 09-0034 Acute Flu Study The Project labs are designing and performing experiments DMID 10-0011 Inactivated Vaccine for Novel H1N1 Virus The Project labs are reporting findings and publishing papers The Data Management team is collecting, storing, and reporting on the data DMID 08-0059 H5 Revax Study DMID 09-0085 Pregnancy PBMC Study Projects 1, 2, 3, 4, 5, Pilot/Supplements Data Management

  12. In our studies, 790 subjects have been enrolled and 48,000+ specimens processed! PRESENT Current Status April 2011 Study Enrollment, Samples, Data Management The data for all these subjects and specimens is located in the Data Management repository

  13. PRESENT Current Status April 2011 Publications Using the inventory of specimens and data, the Immunology research projects have been performing experiments and publishing papers Yr 2 Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design. Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ. J Immunol. 2008 Sep 1;181(5):3039-48.PMID: 18713974 [PubMed - indexed for MEDLINE] PMID18713974 Yr 3 Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus. Richards KA, Chaves FA, Sant AJ. J Virol. 2009 Jul;83(13):6566-77. Epub 2009 Apr 22.PMID: 19386707 [PubMed - indexed for MEDLINE] PMID19386707 The Virology research projects are performing experiments and publishing papers Abortive activation of CD4 T cell responses during competitive priming in vivo. Weaver JM, Chaves FA, Sant AJ. Proc Natl Acad Sci U S A. 2009 May 6;106(21):8647-52. Epub 2009 May 7.PMID: 19423666 [PubMed - indexed for MEDLINE] PMID19423666 Yr 4 Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Desmet, E. A., J. A. Hollenbaugh, P. J. Sime, T. W. Wright, D. J. Topham, A. J. Sant, T. Takimoto, S. Dewhurst, and S. B. Maggirwar. 2010. . Virology 400:224-232. Virology. 2010 May 10;400(2):224-32. Epub 2010 Feb 25. Modifications to the hemagglutinin cleavage site control virulence of a neurotropic H1N1 influenza virus. Sun, X., Tse, L. P. Ferguson, A.D. and Whittaker, G.R. (2010). . J. Virol. 84: 8683-8690. J Virol. 2010 Sep;84(17):8683-90. Epub 2010 Jun 16. CD4 T cells generated from encounter with the seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus. Richards KA., Topham DT, Chaves FA, Sant A.J. (2010). . Cutting Edge: J. Immunol. 185:4998-5002. J Immunol. 2010 Nov 1;185(9):4998-5002. Epub 2010 Oct 1.

  14. PRESENT Current Status April 2011 Publications - continued Yr 4 PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T. J Virol. 2010 May;84(9):4395-406. Epub 2010 Feb 24. PMID: 20181719 [PubMed - indexed for MEDLINE] Identification of a Unique Population of Tissue-Memory CD4+ T Cells in the Airways after Influenza Infection That Is Dependent on the Integrin VLA-1. Chapman, T. J., and D. J. Topham. 2010. . J Immunol 184:3841-3849. J Immunol. 2010 Apr 1;184(7):3841-9. Epub 2010 Mar 3. Biochemical characterization of enzyme fidelity of influenza A virus RNA polymerase complex. Shilpa Aggarwal, Birgit Bradel-Tretheway, Toru Takimoto, Stephen Dewhurst, and Baek Kim. . PLosOne 5:e10372, 2010. PLoS One. 2010 Apr 29;5(4):e10372. B cell responses to H5 influenza HA in human subjects vaccinated with a drifted variant. Baer, J., F. Santiago, H. Yang, H. Wu, W. Jeanne Holden, J. Treanor, and D. J. Topham. . Vaccine 28:907-915. Vaccine. 2010 Jan 22;28(4):907-15. Epub 2009 Nov 21. Analyses of the Specificity of CD4 T cells during the Primary Immune Response to Influenza Virus Reveals Narrow Immunodominance and an Unexpected Asymmetry in Reactivity to Viral Proteins. Nayak, J. L., Richards, K. A. Chaves, F.A. and Sant, A. J. 2010. Viral Immunol. 23(2):169-80. Viral Immunol. 2010 Apr;23(2):169-80. T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model. Guo, H., F. Santiago, K. Lambert, T. Takimoto, and D. J. Topham. 2011. . J Virol 85:448-455. J Virol. 2011 Jan;85(1):448-55. Epub 2010 Oct 27. PMID: 20980523

  15. PRESENT Current Status April 2011 Publications & Projection 13 publications to date. Outlook is for additional 15 publications for each of the remaining 3 years

  16. April 2011 PRESENT Current Status Aims …As we kickoff Year 5, the research projects have aims set forth to investigate

  17. PRESENT Current Status April 2011 Aims - continued

  18. What’s in store for the remaining 3 years of the contract…. FUTURE Next 3 Years April 1, 2011 – March 31, 2014 Goals … Working together to achieve great advances in research

  19. 5 We will continue to enroll subjects, collect blood, process and store speciemens, store and report on the data, and perform research… FUTURE Goals Year Continue Apr 2011 – Mar 2012 (Current Year) • DMID 07-0043 College Student Surveillance Study • DMID 07-0046 Family Surveillance Study …as well as perform monthly reporting and position ourselves for contract renewal • DMID 07-0090 Healthy Donor Study • DMID 09-0085 Pregnancy PBMC Study • DMID 09-0034 Acute Flu Study • DMID 08-0059 H5 Revax Study • Projects 1, 2, 3, 4, 5, Pilots/Supplements • ImmPort – Upload data associated with publications • Publications - published Plus • Determine/consensus on sample needs for project aims • Data Management – LabKey Implementation • External Advisory Committee – August 29, 30 • Host the HIPC/CEIRS Joint Meeting - TBD • Monthly Status Reporting • Monthly Invoicing • Position for renewal

  20. 6 FUTURE Goals Year Continue Apr 2012 – Mar 2013 • DMID 07-0043 College Student Surveillance Study • DMID 07-0046 Family Surveillance Study There will certainly be new ideas and breakthroughs along the way… • DMID 07-0090 Healthy Donor Study • DMID 09-0085 Pregnancy PBMC Study • DMID 09-0034 Acute Flu Study • DMID 08-0059 H5 Revax Study • Projects 1, 2, 3, 4, 5, Pilots/Supplements • Data Management • Publications - published • ImmPort – Upload data associated with publications • Monthly Status Reporting • Monthly Invoicing • Position for renewal

  21. 7 FUTURE Goals Year Continue Apr 2013 – Mar 2014 • DMID 07-0043 College Student Surveillance Study That lead the NYICE to… • DMID 07-0046 Family Surveillance Study • DMID 07-0090 Healthy Donor Study • DMID 09-0085 Pregnancy PBMC Study • DMID 09-0034 Acute Flu Study Provide a truly transforming approach to influenza Research • DMID 08-0059 H5 Revax Study • Projects 1, 2, 3, 4, 5, Pilots/Supplements • Publications - published • ImmPort – Upload data associated with publications • Monthly Status Reporting • Monthly Invoicing Plus • Prepare for startup of renewal • Close down current project contract • Disposition samples • Publish Publications • File documentation • Final report to NIAID

  22. Taking knowledge gained from the past to build upon today and together make a difference in the world

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