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Impact of TLR4 Deficiency on Gene Expression and Tumor Development in Adenoma Growth

This study explores the effects of TLR4 deficiency on various gene expressions associated with tumor growth and inflammation. Key findings include alterations in chemokines like CCL5, SPP1, and cytokines such as IL1RN. The investigation highlights how TLR4 sufficiency influences cellular responses, affecting adenoma development via pathways linked to EGFR signaling, cell proliferation, and inflammatory responses. Results reveal significant changes in gene expression profiles in BALB mice, identifying genes that are increased or decreased post-chronic BHT exposure.

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Impact of TLR4 Deficiency on Gene Expression and Tumor Development in Adenoma Growth

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  1. A. TLR4 deficiency Gja1 Hmga1 Timp2 Ereg Areg Spp1 Hbegf Ran Tnc EGFR family Myc Mina Cell growth & cell cycle Promotion of adenoma development Spp1 Pf4 Cxcl5 Cxcl11 B. TLR4 deficiency Cxcl9 Ccr1 Chst1 MCP-1 Enpp2 MCP-1 S100a8 Cxcl2 Kng1 Ccr2** Ccl5* Inflammatory Response TLR4 sufficiency Spp1 Chemotaxis Utrn Il1rn Tumor growth and progression Ereg Pthlh Arg1 Odc1 EGFR signaling Cell proliferation Genes increased in BALBLpsd 1 day following chronic BHT Genes decreased in BALBLpsd 1 day following chronic BHT Genes increased in BALB 1 day following chronic BHT Genes increased in BALBLpsd tumors Genes decreased in BALB tumors Genes increased in BALB tumors No change in transcript

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