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glucoPHYTON

glucoPHYTON. Rationale of the project and description of ingredients. OBJECTIVES. Design of a phytonutraceutical formulation to: Control post- prandial plasma glucose levels by A) reducing glycemic index of food B) increasing glucose excretion

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glucoPHYTON

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  1. glucoPHYTON Rationale of the project and description of ingredients

  2. OBJECTIVES Design of a phytonutraceutical formulation to: Control post-prandial plasma glucose levels by • A) reducing glycemic index of food • B) increasing glucose excretion Reduce the synthesis of Advanced Glycation End products (AGEs) Reduce the synthesis of Advanced Lipoperoxydation End Products (ALEs) As a consequence of these goals, to prevent and/or to decrease complications of diabetes

  3. INGREDIENTS L-carnosine Pyridoxal-5-phosphate Morus alba Innovative blend combining inhibitors of Glycosidase, inhibitors of SGLT-2 (sodium-glucose cotransporter 2) and inhibitors of the synthesis of Advanced Glycation End products and the synthesis of Advanced Lipoperoxydation End products

  4. Apple TREE BARK PharmacologicalEvidences Phlorizinis a well-known SGLT-2 inhibitor, causing glucosuria both in dogs and humans

  5. PHARMACOLOGICAL EVIDENCES 1-deoxynojirimycin (DNJ) and some of its derivatives are well known as an alpha-glucosidaseinhibitors CLINICAL EVIDENCES • Randomized open, cross-overstudy in 10 healthywomengivenM.albaextract and selectedcarbohydrates • Suppresion of post-prandialbloodglucose and insulinlevels

  6. PHARMACOLOGICAL EVIDENCES • Carnosineinhibits in vitro low-density • Lipoproteinoxydation • Carnosinedelayssenescence of human • cultureddiploidfibroblasts CLINICAL EVIDENCES • Randomizeddoubleblind placebo controlled • study of effectsoncognition and mood in • the healthy elderly volunteers • Working memory (Bond-Lader visual analogue • Scales) increased in 28 subjects after two months • of treatment.

  7. PHARMACOLOGICAL EVIDENCES • Decrease of beta-amyloid-induced • cognitive dysfunction and neurotoxicity • Protective effect on Abeta(1-42)-induced • neuronal cell death and memory impair- • ment of mice. CLINICAL EVIDENCES • Doubleblind, placebo controlledstudy of effects of 100 mg of L-theanine • + 50 mg of caffeineon EEG and scores of attentiontests in 16 healthy • volunteers • Doubleblind, placebo controlledstudy of effects of 100 mg of L-theanine • + 50 mg of caffeineoncognition and mood in healthy volunteers.

  8. INDICATIONS HEALTHY • Increase of attention and short termmemory • Increase of cognitivefunction • Increase of alertness • Decrease of neuronal degenerationduetosenescence, toxins • and oxidativedamage PATIENTS • Decrease of neuronal degeneration in Alzheimer patients • Protective effect on environmental toxins-induced neuronal cell death • Mood improvement in children with attention deficit with hyperactivity

  9. SUMMARY • New formulationnotdescribedelsewhere • Activity of ingredientsdemonstrated in “vitro” and “in vivo • pharmacologicalstudies • Wellknown and safeingredients, most of themwith a specifmonograph in • US Pharmacopea and/orotherpharmacopeas • Ingredientseasylyavailable • Alltheingredientshaveshown beneficial effectsoncognitivefunction, • memory and mental altertness in EvidenceBasedClinicalTrials • Formulationuseful in children, adults and elderly • Formulationlikelyusefulbecauseitconsidersmost of theknownmechanismsinvolved in cognitiva function

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