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Universal Predictors of Abstinence Duration in International Clinical Trials: a Comprehensive Analysis

This study examines predictors of abstinence duration in alcohol dependence treatment across 16 European and US trials. Results indicate a universal model, highlighting factors like baseline severity, medication compliance, living situation, and more. The interaction between treatment types and study locations was not significant.

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Universal Predictors of Abstinence Duration in International Clinical Trials: a Comprehensive Analysis

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  1. Outcome Predicators for Rate of Cumulative Abstinence Duration from Individual Patient Data across 16 European and U.S. Double-Blind Placebo-Controlled Trials (N=4457) • A universal model of predictors of outcome was shown to fit all studies • abstinence at the onset of treatment • medication compliance, both initial and continued • moderate baseline alcohol dependence severity • living with a partner and child • There was no significant interaction between treatment and whether the study was US or European

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