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NEPHROTIC SYNDROME

NEPHROTIC SYNDROME. Common Causes of Benign Proteinuria Dehydration Emotional stress Fever Heat injury Inflammatory process Intense activity Most acute illnesses Orthostatic (postural) disorder. NEPHROTIC SYNDROME. PROTEINURIA EDEMA HYPERLIPIDEMIA LIPIDURIA HYPERCOAGULABILITY.

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NEPHROTIC SYNDROME

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  1. NEPHROTIC SYNDROME

  2. Common Causes of Benign Proteinuria Dehydration Emotional stress Fever Heat injury Inflammatory processIntense activity Most acute illnesses Orthostatic (postural) disorder

  3. NEPHROTIC SYNDROME • PROTEINURIA • EDEMA • HYPERLIPIDEMIA • LIPIDURIA • HYPERCOAGULABILITY

  4. CAUSES OF HYPERLIPIDEMIA • INCREASED LIPOPROTEIN SYNTHESIS • INCREASED LOSS OF REGULATOR PROTEINS • DEFECTIVE LIPID CATABOLISM

  5. CAUSES OF HYPERCOAGULABILITY • DECREASED ANTITHROMBIN III • DECREASED PROTEIN S & C • HYPERFIBRINOGENEMIA • ICREASED PLATELET AGGREGABILITY

  6. OTHER METABOLIC COMPLICATION • PROTEIN MALNUTRITION • ANEMIA • HYPOCALCEMIA • DECREASED THYROXINE LEVEL • SUSCEPTIBILITY TO INFECTION

  7. POOR PROGNOSIS FACTORS IN MGN • MALE SEX • HYPERTENSION • DECREASED GFR • OLD AGE • SEVERE PROTEINURIA • SEVERE HYPERLIPIDEMIA

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