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What is CDNF?

What is CDNF?. C onserved D opamine N eurotrophic F actor Growth factor known as a trophic factor Stimulates the growth of neurons. Recent In Vivo Studies. Scientists need rats that exhibit Parkinson’s-like symptoms Administer 6-Hydroxydopamine (6-OHDA) Kills off Dopaminergic neurons

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What is CDNF?

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  1. What is CDNF? • Conserved Dopamine Neurotrophic Factor • Growth factor known as a trophic factor • Stimulates the growth of neurons

  2. Recent In Vivo Studies • Scientists need rats that exhibit Parkinson’s-like symptoms • Administer 6-Hydroxydopamine (6-OHDA) • Kills off Dopaminergic neurons • Induces Parkinson’s-like symptoms 6-hydroxydopamine L-Dopa Dopamine

  3. Important Lab Findings • CDNF was injected into Striatum of rats before 6-OHDA • CDNF prevented PD symptoms from occurring • Rats were treated to express PD symptoms • Injected with 6-OHDA • 4 weeks later, treated with CDNF • Neuron function and viability was restored

  4. http://www.pharmacy.ac.uk/1638.html

  5. Screening Patients • Adequate patient response to L-Dopa • Indicates DA neurons are degraded but treatable • No effect of L-Dopa • Indicates that DA neurons have degraded completely http://www.physorg.com/news/2010-10-parkinson-disease-closer.html

  6. Benefits in human trials • CDNF has a “protective” effect • Prevents neuron degradation • CDNF can restore up to 98% function • Promoting DNA replication • Can be administered through lumbar puncture • Out-patient procedure • Anaesthetized for comfort • Use Mannitol to penetrate the Blood-Brain-Barrier

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