Download
slide1 n.
Skip this Video
Loading SlideShow in 5 Seconds..
Phosphoribosyl Pyrophosphate (PRPP) PowerPoint Presentation
Download Presentation
Phosphoribosyl Pyrophosphate (PRPP)

Phosphoribosyl Pyrophosphate (PRPP)

187 Vues Download Presentation
Télécharger la présentation

Phosphoribosyl Pyrophosphate (PRPP)

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. Pentose Phosphate Pathway Phosphoribosyl Pyrophosphate (PRPP) Amidophosphoribosyl-transferase (commitment step) 5-phosphoribosylamine Complex Pathway IMP dehydrogenase Adenylosuccinate synthase Xanthosine Monophosphate (XMP) Inosine Monophosphate (IMP) Adenylo-succinate Adenylosuccinate lyase GMP synthase GMP reductase AMP deaminase Guanine Adenine Nucleotidase Inosine Purine Nucleosidase/Phosphorylase Guanase Hypo-xanthine Xanthine oxido-reductase Xanthine oxoreductase Uric Acid Xanthine

  2. AMP deaminase: Missing EC 3.5.4.6, an adenosine monophosphate deaminase. Both JGI and Manatee call an adenosine deaminase with EC 3.5.4.- Guanase: Missing EC 3.5.4.3, a guanine deaminase. RAST calls a hypothetical protein with EC 3.5.4.3 AT THE EXACT SAME BASE PAIRS that JGI and Manatee called an adenosine deaminase. Xanthine oxidoreductase: Missing EC 1.17.3.2 or 1.17.1.4. Xanthine oxoreductase: Same EC numbers as Xanthine Oxidoreductase OVERARCHING QUESTIONS: Is it an adenosine monophosphate deaminase or a guanine deaminase? What is xanthine and why does our organism appear to have no ability to do anything with it (same with other halophiles)?

  3. BLAST Result for adenosine / guanine deaminase: Most were cytidine deaminases… But the second highest result was a guanine deaminase! Conclusion: Possibly a guanine deaminase?