1 / 57

VGCC

NCE. mM [Ca]. NMDA, AMPA rec. nAChR. CNG. VR/temp rec. VDAC. Stretch receptor. TRP. mM [Ca]. SOC. IP3R. SERCA. 100 nM [Ca]. ROC. VGCC. mM [Ca]. PMCA. RyR. SERCA. Sarcoplasmic Reticulum (SR) / T Tubule System. Twitch. Summation. Tetanus. Role of Ca ++ in contraction.

ondrea
Télécharger la présentation

VGCC

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. NCE mM [Ca] NMDA, AMPA rec nAChR CNG VR/temp rec VDAC Stretch receptor TRP mM [Ca] SOC IP3R SERCA 100 nM [Ca] ROC VGCC mM [Ca] PMCA RyR SERCA

  2. Sarcoplasmic Reticulum (SR) / T Tubule System

  3. Twitch

  4. Summation

  5. Tetanus

  6. Role of Ca++ in contraction

  7. vertebrate skeletal muscle contraction

  8. Excitation-contraction coupling Ryanodine receptors

  9. RyR

  10. 500 1000 NH2 PP1 MH/CCD 1500 2000 DHPR/RyR1 PP2A FKBP MH/CCD 2500 Ca-Activation 3000 P 3500 mAKAP RII-PKA PKA/CamKII PO4 site Calmodulin Ca-Inactivation 4000 5000 4500 CO2H Ryanodine Cytosol RyR2 SR Membrane GIG M1 M2 M3 M4 Lumen MH/CCD

  11. Voltage-gated ion channels

  12. Regulation of EC coupling by adrenergic signaling -- “fight or flight”

  13. RyR2 macromolecular complex

  14. RyR macromolecular complexes are held together by leucine/isoleucine zippers

  15. RyR2/calcium release channel phosphorylated by addition of cAMP alone

  16. PKA phosphorylation activates RyR2 and induces subconductance states

  17. RyR2 open probability Iso CHF ECC gain Ca transient contractility [Ca] DADs - SCD Cytosolic [Ca] Time

  18. Excitation-secretion coupling Inositol 1,4,5-trisphosphate receptors

  19. IP3 signaling

  20. Stable transfectant Jurkat T cells do not express IP3R1 IP3R1

More Related