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Comprehensive TET HTCA Assay of Compound Class EL: Binding Affinities and Analysis

This table summarizes the TET HTCA assay results for various compounds classified under EL, showcasing their binding affinities measured in micromolar (μM). The data includes the average binding affinities for compounds such as BJFL018, BJFL034, C&R-5, C&R-6, CHOR2, CHOR3, CS36, and DRF039, with associated standard deviations across different concentrations. This information aids in understanding the efficacy of these compounds for further pharmacological studies.

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Comprehensive TET HTCA Assay of Compound Class EL: Binding Affinities and Analysis

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  1. Supplemental Table 2 TET HTCA ASSAY COMPOUND CLASS EL T1 T2 OFF ON 0.07μM ± 0.03 0.05μM ± 0.004 0.057μM ± 0.01 BJFL018 Meriolins 0.08μM ± 0.02 0.05μM ± 0.004 0.058μM ± 0.003 0.05μM ± 0.01 0.03μM ± 0.004 0.042μM ± 0.02 OFF ON BJFL034 0.05μM ± 0.01 0.031μM ± 0.002 0.041μM ± 0.02 0.26μM ± 0.03 0.75μM ± 0.01 0.27μM ± 0.04 OFF ON C&R-5 0.29μM ± 0.04 0.68μM ± 0.02 0.26μM ± 0.03 0.57μM ± 0.26 1.46μM ± 0.03 0.41μM ± 0.05 OFF ON C&R-6 0.57μM ± 0.22 1.38μM ± 0.08 0.42μM ± 0.02 0.76μM ± 0.07 2.43μM ± 1.04 0.72μM ± 0.05 OFF ON CHOR2 Purines 0.75μM ± 0.05 2.17μM ± 0.83 0.69μM ± 0.04 0.54μM ± 0.18 1.35μM ± 0.07 0.58μM ± 0.04 OFF ON CHOR3 0.57μM ± 0.13 1.35μM ± 0.07 0.57μM ± 0.04 1.43μM ± 0.79 1.08μM ± 0.06 1.34μM ± 0.39 OFF ON CS36 1.46μM ± 0.87 1.02μM ± 0.03 1.23μM ± 0.53 OFF ON 6.67μM ± nd nd 5.13μM ± nd DRF039 7.18μM ± nd nd 5.64μM ± nd

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