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Innovative Noninvasive Electrical Stimulation for Epilepsy Management

This research focuses on the noninvasive technique of Trans Focal Electrical Stimulation (TFES) using Tripolar Concentric Ring Electrodes (TCRE) to treat epilepsy and improve life for those with severe motor disabilities. TFES aims to control seizures, enhance detection capabilities, and provide a higher success rate without surgical complications. The University of Rhode Island's study emphasizes how this method efficiently isolates signals and reduces interference. Animals were used in approved protocols for data collection, contributing to promising advancements in epilepsy treatment and brain-computer interfaces.

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Innovative Noninvasive Electrical Stimulation for Epilepsy Management

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  1. Brown Gold Yellow Blue URI Based Research on Noninvasive Electrical Stimulation and Epilepsy Riley Davis Biomedical Engineering University of Rhode Island

  2. Introduction • What is epilepsy? • Who gets epilepsy? • What is a seizure and how does it occur? • How is epilepsy treated?

  3. Research • Noninvasive Trans Focal Electrical Stimulation (TFES) • Tripolar Concentric Ring Electrodes (TCRE) • Neurotransmitters • Recordings/data

  4. Purpose • Brain Computer Interface • Help people with severe motor disabilities • Epilepsy Research • Noninvasive • Early detection • Control seizure • Higher success rate

  5. Process All animal protocol was approved by the University of Rhode Island IACUC. • TCRE • Observe/record • Detect • Transmit • Observe/record • Video

  6. Advantages • TCRE • Significantly reduce signals from undesired sources. • Isolate the signals from sources more effectively • Function externally/noninvasively • Removes complications involved with surgery and side effects

  7. New Data

  8. The Team POSTDOCTORAL FELLOWS UNDERGRADUATE STUDENTS Alejo, Cesar Perez, Christian J. Togba, Michelle Makeyev, Oleksandr, Ph.D.  Mucio, Samuel, M.S Lui, Xiang, M.S. INVITED SCHOLARS GRADUATE STUDENTS

  9. Resources • Beghi, E., et al. (2005). Comment on Epileptic Seizures and Epilepsy: Definitions Proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 46(10), 1698–1699. • Sander, J. W. (2003). The Epidemiology of Epilepsy Revisited. Current Opinion in Neurology, 16(2), 165–170. • Besio, W. G., et al. (2011). Transcutaneous Focal Electrical Stimulation via Concentric Ring Electrodes Reduces Synchrony Induced by Pentylenetetrazole in BETTA and GAMMA Bands in Rats. International Journal of Neural Systems, 21(2), 139–149. • During, M. J. (2002). Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature, 376, 174-177. • Xi, Z., & Gardner, E. L. (2008). Hypothesis-Driven Medication Discovery for the Treatment of Psychostimulant Addiction. Curr Drug Abuse Rev, 1(3), 303–327. • Besio, W. G., et al. (2007) Feasibility of noninvasive transcutaneous electrical stimulation for modulating pilocarpine-induced status epilepticus seizures in rats, Epilepsia 48(12) 2273–2279.

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