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The Life-Changing Benefits of Regular Exercise: A Comprehensive Overview

Discover the transformative effects of regular exercise on overall health, including decreased mortality and reduced risk of conditions such as cardiovascular disease, obesity, diabetes, and cancer. Engaging in consistent physical activity not only enhances physical capacity and skin health but also boosts mental well-being. Target a heart rate of 70-85% for optimal benefits, aiming for at least 30 minutes of moderate exercise five times a week. Embrace these lifestyle changes to improve your general health and longevity.

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The Life-Changing Benefits of Regular Exercise: A Comprehensive Overview

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  1. The Miracle of Exercise J. Kelly Smith, M.D., F.A.C.P.

  2. Benefits • Decreases all cause mortality • Cardiovascular disease • Cancer • Helps prevent overweight, obesity • Lowers risk of type 2 diabetes mellitus • Lowers lipid levels • Lowers blood pressure • Lowers myocardial oxygen demands • Lowers risk of osteoporosis • Improves general health • Improves physical working capacity • Improves skin health • Improves mental outlook and acuity

  3. Exercise target • Calculate maximum heart rate (MHR = 220 – age) • Start @ 40-50% of MHR • Target = 70-85% of MHR • Target ≥ 30 minutes/day 5 days/week

  4. Atherogenesis

  5. Atherogenesis

  6. Atherogenesis

  7. Exercise & mononuclear cell function • Six months of moderate intensity exercise • Decreased atherogenic cytokine production by peripheral blood mononuclear cells by 58.3% (P<0.001) • Increased atheroprotective cytokine production by peripheral blood mononuclear cells by 35.9% (P<0.001) • Decreased CRP levels by 35% Smith JK, Dykes R, Douglas JE, Krishnaswamy G, Berk S. JAMA 1999:281;1722-1727

  8. Exercise & atherogenesis

  9. Exercise & atherogenesis

  10. Exercise & VEC function Habitual moderate intensity aerobic exercise stimulates an an atheroprotective VEC phenotype • Augments endothelial nitric oxide-dependent vasodilatation • Aids in normalizing shear stress effects on VEC function and on arterial remodeling • Reduces risk factors that adversely effect VEC function • Reduces proinflammatory effects of white adipose tissue on VEC function

  11. Exercise & atherogenesis A Quid Pro Quo Relationship

  12. Exercise & HIV

  13. Exercise & HIV

  14. Exercise & HIV

  15. Exercise & HIV

  16. Exercise & HIV

  17. Exercise & HIV

  18. Exercise & HIV

  19. Exercise & HIV

  20. Exercise & Obesity

  21. Exercise & Obesity

  22. Exercise & Obesity Adaptive thermogenesis

  23. Exercise target • Calculate maximum heart rate (MHR = 220 – age) • Start @ 40-50% of MHR • Target = 70-85% of MHR • Target ≥ 30 minutes/day 5 days/week

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