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Advanced Characterization of Platelet Activation Using Microfluidics and Electrode Methods

The Platelet Project aims to innovate platelet analysis by utilizing microfluidics and electrochemical impedance spectroscopy (EIS) to assess the activation grade of individual platelets. By employing a two-phase system, we enhance the signal-to-noise ratio (SNR) of our measurements. Additionally, hydrodynamic 3D focusing helps to maintain platelets away from channel walls, improving accuracy. We also explore laser ablation techniques to fabricate fluidic channels and conduct bulk EIS studies, including tests in an electroporation cuvette with aluminum electrodes.

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Advanced Characterization of Platelet Activation Using Microfluidics and Electrode Methods

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Presentation Transcript

  1. The platelet project

  2. The platelet project – main idea • Use microfluidics and EIS to characterize the activation grade of single platelets • Use a 2-phase system to increase the SNR • Use hydrodynamic 3D-focusing to keep the platelets off the channel walls • Use laser ablation to create simple fluidic channels

  3. Simulations

  4. Bulk EIS studies • Bulk platelet tests using an electroporationcuvette with aluminum electrodes

  5. Bulk EIS studies

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