1 / 10

CNS fungal infections

CNS fungal infections. Fungal infections. Cryptococcal meningitis (AIDS) Candida meningitis (neonates and neurosurgery) Brain abscesses. Cryptococcoal meningitis. Caused by one of two species: Cryptococcus neoformans Cryptococcus gattii

osmond
Télécharger la présentation

CNS fungal infections

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CNS fungal infections

  2. Fungal infections • Cryptococcal meningitis (AIDS) • Candida meningitis (neonates and neurosurgery) • Brain abscesses

  3. Cryptococcoal meningitis • Caused by one of two species: • Cryptococcus neoformans • Cryptococcus gattii • Acquired by inhalation of the basidiospore from the environment

  4. Cryptococcoal meningitis • AIDS defining opportunistic infection • Other increased risk populations include: • Lymphomas (e.g.Hodgkin's lymphoma) • Long-term corticosteroid therapy

  5. Diagnosis • Symptoms: Fever, fatigue, headache, neck stiffness, blurred vision and confusion • CSF examination and culture • India ink capsule staining • Detection of cryptococcal antigen (capsular material) • Capsulated yeast in culture Note: Candida species is not capsulated

  6. Fungal Brain infections • Apergillus species • Scedosporiumapiospermum • Zygomycetes • Candida species • Pigmented fungi: • Rhinocladiella mackenziei (Phaeohyphomycosis) • Cladophialophora(Phaeohyphomycosis) • Exophiala(Phaeohyphomycosis) • Fonsecaea (Phaeohyphomycosis)

  7. A case of Scedosporiumapiospermumbrain infection • A 51-year-old farmer had a near-drowning • Developed bronchopneumonia and treated with antibiotics • Two weeks later the patient developed bifrontal headache, with features suggestive of raised intracranial pressure. 

  8. Laboratory diagnosis Clinical material: • Aspirated pus • CSF • Tissue biopsies Direct Microscopy: • 10% KOH, H&E, PAS and Silver stain Culture: • SDA and BHIA

  9. Management • Surgical excision or drainage • Antifungal (Amphotericin B or Azoles)

More Related