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BIOIDENTICAL HORMONE REPLACEMENT M. LITMAN, M.D. JUNE, 2009

WOMEN'S HEALTH INITIATIVE STUDY OVER 16, 000 WOMEN.. PREMPRO (PREMARIN/PROVERA)VS.PLACEBO Breast cancer increased by 26%CVD increased by 29%Stroke increased by 41%Blood clots increased by 100%. WHI. ? It remains possible that transdermal estradiol with progesterone, which more closely mimics t

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BIOIDENTICAL HORMONE REPLACEMENT M. LITMAN, M.D. JUNE, 2009

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    1. BIOIDENTICAL HORMONE REPLACEMENT M. LITMAN, M.D. JUNE, 2009

    2. WOMENS HEALTH INITIATIVE STUDY OVER 16, 000 WOMEN. PREMPRO (PREMARIN/PROVERA)VS.PLACEBO Breast cancer increased by 26% CVD increased by 29% Stroke increased by 41% Blood clots increased by 100%

    3. WHI It remains possible that transdermal estradiol with progesterone, which more closely mimics the normal physiology and metabolism of endogenous sex hormones, may provide a different risk-benefit profile. Writing Group for WHI, July 2002

    4. HORMONE PATHWAYS IN OVARIES AND ADRENAL GLANDS Cholesterol Pregnenolone Progesterone Hydroxypregnenolone DHEA Deoxycorticosterone Hydroxyprogesterone Androstenedione Corticosterone Deoxycortisol Oestrone Testosterone Aldosterone Cortisol Oestriol Oestradiol

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