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拉唑类质子泵抑制剂

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拉唑类质子泵抑制剂. PPI 作用过程. 质子泵： H+/K+-ATP 酶 作用方式：抑制质子泵 作用过程：. 代表药物. 第一代 PPI. 第二代 PPI. 第一代 PPI 药物. 第二代 PPI 药物. 埃索美拉唑. 埃索美拉唑. 埃索美拉唑.

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拉唑类质子泵抑制剂

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  1. 拉唑类质子泵抑制剂

  2. PPI作用过程 • 质子泵：H+/K+-ATP酶 • 作用方式：抑制质子泵 • 作用过程：

  3. 代表药物 第一代PPI 第二代PPI

  4. 第一代PPI药物

  5. 第二代PPI药物

  6. 埃索美拉唑

  7. 埃索美拉唑

  8. 埃索美拉唑

  9. 埃索美拉唑与R - 异构体一样,在肝脏完全经细胞色素P450 酶系统代谢，包括代谢速率快的CYP2 C19途径和代谢速率较慢的CYP3A4途径。73%的埃索美拉唑、98%的R - 异构体通过CYP2 C19代谢, 27%的埃索美拉唑、2%的R - 异构体通过CYP3A4代谢。与R - 异构体相比,埃索美拉唑更少由CYP2 C19代谢,其清除率明显低于R - 异构体。

  10. Thank You !

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