NOVACOC FORTE

3. Ingredients: Glucose monohydrate: basic essential energy supply for organism Action: providing direct essential „fuel“ via bloodstream necessary for ALL life processes in ruminants (cow, sheep goat): especially important for the lactating cow (lactose): more than 4kg glucose requirement for about 60kg milk energy for milk fat synthesis requires glucose Result: prompt improvement of clinical signs (energy) milk production can be maintained NOVACOC FORTE

4. Ingredients: calcium digluconate: major electrolyte in animal body (bone, teeth) Action: necessary for: normal cardiac rythm neuromuscular activity metabolic activity In ruminants: last month fetus growth: 0.2g Ca/hour! Start of lactation (20kg milk): 1.0gCa/hour! hypocalcaemia (can occur in all species!) Result: correction of immediate imbalance until homeostatic mechanism has adapted to the situation NOVACOC FORTE

5. Ingredients: Metamizole (novaminsulfone, dipyrone): Non Steroidal Antiphlogistic Inflammatory Drug Action: inhibition of peripheral prostaglandin synthesis (E2) thus inhibiting: pain superoxide radicals generation bradycinin action enzyme release (lysomal ones) distinct spasmolytic effect on smooth muscle tissues Result: spasmolytic, antipyretic antiphlogistic effects NOVACOC FORTE

6. Ingredients: acetylmethionine: essential sulphur containing amino acid! Action: source for cysteine (only known 2nd amino acid with sulphur) essential for gluthathione peroxidase (red blood cells) source for sulphur: ATP production oxygen transport Result: efficient function of sulphur dependant systems in body NOVACOC FORTE

7. Ingredients: Magnesium gluconate: synergism with Ca, against electrolyte deficiency Action: guarantees physiological function of: phosphate transfer muscle contractibility neuronal transmission ruminants: often seen in early lactating cows: ataxia, collapse in young suckled beef calves: sudden death in chronic cases: decreased appetite reduction in milk yield Results: prevents disturbances in tissue functions normalises electrolyte balance

8. Ingredients: Caffeine: circulatory stimulating substance Action: inhibition of adenosin receptor blocade (main action) raise in blood pressure increase in turnover of neurotransmitters increases sthrength and duration of contraction (cardial and skeletal muscles) Results: enhancement of body functions (circulation, CNS)

9. Dosage: Horses (350-600kg): 150-250ml Horses (200-350kg): 100-150ml Adult cattle: 100-250ml Calves, Young cattle : 50-100ml Pigs: 20 - 50ml

10. Side effects: too fast infusion can cause tachycardia cardiac arrythmia Overdosage: if administered too quickly collapse cardiac disturbances Tolerance was proven to be very good! (E. Glawischnig, Wr. Tierärztl. Mschr) Cows tolerated 500ml for 7 days without any problems if bodywarm increased breath and puls rate if cold infusion

12. Field trial in about 1000 animals with following diseases: Foreign body peritonitis: partly severe progressive cases liver disease: fatty liver disease degenerative liver disease

13. severe intoxications in different species: cattle (coli mastitis, severe bronchitis), sows (puerperal sepsis), piglets, calves (acute enteritis, diarrhea, bronchopneumonia) sheep (staphylococci mastitis, stenosis of intestine) goat (stenosis of omasum, endometritis)

14. Results of Trial: faster increase of feed intake faster clinical restitution (especially in liver disease) acceleration of recovery (especially in case of intoxication) general recovery faster (than controls)