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Synthesis and Characterization of Novel Double-Functionalized

LIPASE. O. T. (. A. ). R. O. R. O. H. C. +. C. H. O. T. (. A. ). 2. O. Synthesis and Characterization of Novel Double-Functionalized Surface Modified Thermoplastic Elastomers Judit E. Puskas, University of Akron, DMR 0509687.

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Synthesis and Characterization of Novel Double-Functionalized

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  1. LIPASE O T ( A ) R O R O H C + C H O T ( A ) 2 O Synthesis and Characterization of Novel Double-Functionalized Surface Modified Thermoplastic Elastomers Judit E. Puskas, University of Akron, DMR 0509687 Dendritic (arborescent or tree-like (polyisobutylene-polystyrene block copolymers (arbIBS) are the third generation of polyisobutylene (PIB)-based nanostructured biomaterials. The first generation from this class of polymers, linear tri-block polystyrene-b-polyisobutylene-b-polystyrene (SIBS), is FDA-approved and currently used as the polymeric coating on drug-eluting coronary stents (http://www.taxus-stent.com/#, Device Details, Interactive Overview). XPS and AFM studies of SIBS and arbIBS biomaterials demonstrated that a 10 nm layer of pure PIB segregated to the surface during self-assembly of the nanostructure. Functionalization of the PIB segments will yield arbIBS whose surface is decorated with bioactive groups, further improving biocompatibility. This year we explored functionalization using enzymes as catalysts. Students: Elizabeth Foreman (US) Mustafa Sen (Turkey) Lyn Munoz Robledo (US) PDF: Kevin Cong (China) REU Allia Lindsay (2006) Victoria Sane (2007) Joseph Kasper (2007) Candida Antarctica lipase B Thymine Surface functionalization

  2. Puskas Group DMR #0509687 CHE #0616834 # 38895-AC7 DFG

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