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Johns Hopkins Biostatistics for Clinical and Translational Research (Biostat CenTeR)

Johns Hopkins Biostatistics for Clinical and Translational Research (Biostat CenTeR). Service, Innovation, Education. BERD Meeting Bethesda, MD Nov 20-21, 2008. Daniel E. Ford, M.D., M.P.H. Director, Institute for Clinical and Translational Research

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Johns Hopkins Biostatistics for Clinical and Translational Research (Biostat CenTeR)

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  1. Johns Hopkins Biostatistics for Clinical and Translational Research (Biostat CenTeR) Service, Innovation, Education BERD Meeting Bethesda, MD Nov 20-21, 2008 Daniel E. Ford, M.D., M.P.H. Director, Institute for Clinical and Translational Research Vice Dean for Clinical Investigation Scott L. Zeger, PhD Director, Johns Hopkins Biostat CenTeR Vice Provost for Research Michael E. Griswold, PhD Co-Director, Johns Hopkins Biostatistics CenTeR Director, Johns Hopkins Biostatistics Center

  2. Johns Hopkins Institute for Clinical and Translational Research Daniel E. Ford, M.D., M.P.H., ICTR Director Clinical Resources Research participant Recruitment office Advanced Degree-Granting Programs Biostatistics Johns Hopkins ICTR Participant & Community Involvement Study Design Biomedical Informatics Regulatory Support A collaborative group system with overarching goals and responsibilities

  3. Hopkins Biostatistics Key Components • The Johns Hopkins Department of Biostatistics • 25 faculty, 40 PhD students • The Johns Hopkins Biostatistics Center • 4 PhD, 3 masters-level statisticians • Two GCRC Centers for Data Management and Statistics • 3 PhD statisticians, 3 data managers • Oncology Biostatistics • 6 PhD, 6 masters-level statisticians • Center for Clinical Trials • 32 faculty, support staff • Biostatistics Working Groups • 10-20 faculty and students each • K12 Clinical Research Methods Training • 5 faculty, 2 staff • Welch Center for Prevention, Epidemiology and Clinical Research • 25 faculty, 100 staff, and 50 trainees. 4.5 FTEs

  4. Organization: Biostat CenTeRJH Biostatistics for Clinical and Translational Research The Biostat CenTeR is spread throughout JHMI and is comprised of multiple service clusters and an administrative cluster. Faculty innovators are connected to and work with one or more service clusters. Working groups of faculty are represented by faculty symbol colors. Faculty innovators Service cluster Administrative cluster SZ

  5. Biostatistics CenTeR Specific Aims • SERVICE: Institute a biostatistics service organization that supports Johns Hopkins biomedical scientists in clinical and translational research. • INNOVATION: Participate in Multidisciplinary Working Groups to advance targeted clinical and translational research methods • EDUCATION: Promote continual learning of research methodology

  6. SERVICE • Collaboration • Study Design • Data Informatics • Analytics • Translation • Teaching • Biostats Clinics • CRU (GCRC) functions • Protocol Development • Protocol Review

  7. INNOVATION: Multidisciplinary Working Groups for translational research methods Genome Wide Association Studies

  8. EDUCATION: Web Products for Dissemination • Open Courseware • eCollab: A Reproducible Research web-based system for documentation and dissemination: Each significant collaboration will be captured by the creation of a web-page that documents: • The scientific question • Links to background scientific references • The statistical questions • Text describing the recommended solution • Any data analysis results and interpretations • Hyper-links from text to the data set • Software used to implement sample size planning or data analyses

  9. Education: Open Course Ware

  10. Education: Capturing Collaborations

  11. Education: Capturing Collaborations

  12. What’s worked… • Proactive Service: Free “Biostats Clinics” where clinicians gather (the java hut) Plasma Screen Advertisements

  13. What’s worked… • CenTeR wiki • Translational Biostatistics Forums • Continuing Statistical Education • Advancing Service:

  14. What’s worked… • CenTeR wiki • Translational Biostatistics Forums • Continuing Statistical Education • Advancing Service:

  15. What’s worked… • CenTeR wiki • Translational Biostatistics Forums • Continuing Statistical Education • Advancing Service:

  16. What Keeps Me Up At Night…

  17. What Keeps Me Up At Night…  Supply: 4.5 FTEs Demand: • Tracking: • Effort • Outcomes • Administration: • Centralized vs. Decentralized • Research &Translation Career Paths

  18. Johns Hopkins Biostatistics for Clinical and Translational Research (Biostat CenTeR) Service, Innovation, Education BERD Meeting Bethesda, MD Nov 20-21, 2008 Daniel E. Ford, M.D., M.P.H. Director, Institute for Clinical and Translational Research Vice Dean for Clinical Investigation Scott L. Zeger, PhD Director, Johns Hopkins Biostat CenTeR Vice Provost for Research Michael E. Griswold, PhD Co-Director, Johns Hopkins Biostatistics CenTeR Director, Johns Hopkins Biostatistics Center

  19. Reproducible Research & Project Based Learning Education Scientific Question A Research Pipeline Study Design Presentation Code Protocols Analytic Code Text Collection & Informatics Figures Analytic Results Article Analytic Data Tables Measured Data NumericResults Why do we usually only see this? Processing Code

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