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Advancing HIV Research: The ANRS International VISCONTI Post-Treatment Controller Cohort

The ANRS International VISCONTI Cohort aims to establish an international network of Post Treatment Controllers (PTC) to explore mechanisms of HIV remission, identify predictive markers for viral control post-treatment interruption, and increase understanding of epidemiological and clinical characteristics among PTCs. This study will collect data on patient demographics, treatment history, virological/immunological characteristics, and will compare PTCs with patients at varying HIV infection stages. Funded and organized by ANRS, this comprehensive research effort seeks to illuminate potential avenues for safely interrupting HAART.

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Advancing HIV Research: The ANRS International VISCONTI Post-Treatment Controller Cohort

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  1. Kuala Lumpur, July 2nd 2013 The ANRS International VISCONTI Post Treatment Controller Cohort

  2. OBJECTIVES • To build an international cohort of Post Treatment Controllers in order to : • Uncover mechanisms underlying viral control, i.e. HIV remission • Identify predictive markers associated with viral control after treatment interruption • Main Outcome: To identify patients in whom HAART could be safely interrupted

  3. To increase the number of cases: • To describe epidemiological and clinical characteristics of PTC • Age, sex, PHI, Time of treatment initiation, treatment duration, ARV combinations used, transmission group… • To describe Virological and Immunological characteristics • Analyse and quantification of the cellular and anatomical reservoirs • Viral properties and interactions between viral and cellular proteins • Innate and adaptive immunity, antibody response…. • To Compare to other cohortsof patients at different stages of HIV infection: PHI, HIV controllers, Chronic patients, patients on HAART…

  4. Methodology • Inclusion criteria • Treatment initiation with VL >2000 HIV-RNA copies/ml, whatever the timing of infection • Treatment for more than 12 months • Viral control after Treatment interruption below 400 copies/ml for at least 12 months • Data collected once a year

  5. General organisation • Funded and organized : ANRS • International Steering Committee • International Scientific Committee • PI : AsierSaez-Cirionand Laurent Hocqueloux • International recruitment: Two levels of inclusion 1 – with Clinical and epidemiological data 2 – with Clinical and epidemiological data + BIOBANK CONTACT : visconti@anrs.fr

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